class: title # Visualizing Microbiome Data <style> .slide-background { background: url("figures/cover.png") no-repeat center center; background-size: cover; opacity: 0.5; } </style> <div id="subtitle"> Kris Sankaran <br/> AHRI Seminar <br/> 17 | January | 2025 <br/> </div> <div id="subtitle_right"> Slides: <a href="https://go.wisc.edu/i50k4t">go.wisc.edu/i50k4t</a><br/> Examples: <a href="https://go.wisc.edu/9416ze">go.wisc.edu/9416ze</a><br/> Lab: <a href="https://go.wisc.edu/pgb8nl">go.wisc.edu/pgb8nl</a> <br/> </div> <!-- 40 minute talk --> --- ## Visualization Fundamentals --- ### Motivation: Perception If our brains were built differently, we might be able to understand an entire experiment by glancing at a spreadsheet. Even though this is impossible, data visualization can make complex comparisons more automatic. <div style="text-align: center;"> <img src="figures/lion_binary.png" width=1200/> Figure from [1]. </div> --- ### Motivation: Perception If our brains were built differently, we might be able to understand an entire experiment by glancing at a spreadsheet. Even though this is impossible, data visualization can make complex comparisons more automatic. <div style="text-align: center;"> <img src="figures/paradoxes.png" width=1200/> Figure from [2]. </div> --- ### Motivation: Working Memory Statistical thinking allows us to get around our limited working memory. 1. **Compression**: Find a simple representation that captures essential properties of the data. 1. **Focusing**: Narrow down to a subset of the data that is sufficient to answer a question of interest. <div style="display: flex; justify-content: center; max-width: 700px;margin: 0 auto"> <img src="figures/map.png" style="max-width: 70%; height: auto;"/> <img src="figures/microscope.png" style="max-width: 30%; height: auto;"/> </div> --- ## Designing Effective Visualizations --- ### Encoding and Efficiency Different ways of encoding information are perceived with different accuracies. This means that any visualization implicitly prioritizes some comparisons over others. <div style="text-align: center;"> <img src="figures/ranking_encodings.png" width=600/><br/> Figure from [3]. </div> --- How many times larger is the circle on the right? <div style="text-align: center;"> <iframe src="figures/circles.html" style="height: 620px; width: 600px" frameborder="0"></iframe><br/> </div> --- How many times taller is the bar on the right? <div style="text-align: center;"> <iframe src="figures/bars.html" style="height: 620px" frameborder="0"></iframe><br/> </div> --- ### Data-to-Ink Ratio > Premature summarization is the root of all evil in statistics. > > -- Susan Holmes .pull-left[ Good visualizations show more of the data, faithfully represent it, and are memorable. ] .pull-right[ <div style="text-align: center;"> <img src="figures/data_ink2.png" width=450/><br/> Figure from [4]. </div> ] --- ### Data-to-Ink Ratio > Premature summarization is the root of all evil in statistics. > > -- Susan Holmes .pull-left[ Good visualizations show more of the data, faithfully represent it, and are memorable. ] .pull-right[ <div style="text-align: center;"> <img src="figures/data_ink1.png" width=500/><br/> Figure from [4]. </div> ] --- exclude: true <div style="text-align: center;"> <img src="figures/memorable_visualizations.png" width=900/><br/> Figure from [5]. </div> --- ### Faceting It's often surprisingly effective show many similar views in parallel. This is the basis for techniques like small multiples and piling [4; 6] <div style="text-align: center;"> <img src="figures/biome_horizon.png" width=500/><br/> Horizon plot made using the BiomeHorizon package [7]. </div> --- ### Focus-plus-Context We can let readers zoom into patterns of interest without losing relevant context. > Overview first, zoom and filter, then details on demand. -- Schneiderman's "Visual Information Seeking Mantra", from [8]. --- Interactive sankey from the treelapse package [9]. <iframe src="https://krisrs1128.github.io/treelapse/pages/antibiotic.html#interpretation" style="height: 620px; width: 900px" frameborder="0"></iframe><br/> --- ### Dynamic Linking 1. Multiple plots can be "linked" together through interaction. Queries made on one plot can prompt changes across several others. 1. This is one way to implement focus-plus-context: An overview plot can be linked together with a zoomed-in focus. --- ### Linked Views Linking helped us explore a metabolomic dataset from the THOR model microbiome community [10]. B, F, and K are different bacterial species. <iframe src="http://127.0.0.1:5189" style="height: 620px; width: 1000px" frameborder="0"></iframe><br/> --- ## Microbiome Visualization --- ### MA Plot An MA plot [11] is a good first step in a differential abundance analysis. * Minus: Difference in log-abundances between groups. * Average: Average of log-abundances across groups <div style="text-align: center;"> <img src="figures/ma_plot_da.png" width=700/> </div> --- ### MA Plot This is an MA plot comparing low vs. high BMI groups in the Atlas study of healthy European adults [12]. <div style="text-align: center;"> <img src="figures/ma_plot_da.png" width=850/> </div> --- ### ECDF Plots If we want taxa-level detail, we can make an empirical cumulative distribution function (ECDF) plot. This traces `\(\left(t, \mathbf{P}\left(X \leq t\right)\right)\)` for across the range of observed values of `\(t\)`. <div style="text-align: center;"> <img src="figures/ecdf_overall.png"/> </div> --- Unlike histograms, ECDFs don't require any choice of bin width. They perform surprisingly well in studies of uncertainty visualization [13]. <div style="text-align: center;"> <img src="figures/histogram_narrow.png"/> </div> --- Unlike histograms, ECDFs don't require any choice of bin width. They perform surprisingly well in studies of uncertainty visualization [13]. <div style="text-align: center;"> <img src="figures/histogram_wide.png"/> </div> --- ### ECDF Interpretation Here is an ECDF for the same BMI differential analysis from before. Curves further to the right have systematically larger abundances. <div style="text-align: center;"> <img src="figures/ecdf_testing.png"/> </div> --- ### Considerations 1. Which taxa? We typically order the panels using the result of a differential abundance analysis. 1. What scale? Different normalizations will prioritize some differences between groups over others. <div style="text-align: center;"> <img src="figures/ecdf_testing.png"/> </div> --- ### Considerations 1. Which taxa? We typically order the panels using the result of a differential abundance analysis. 1. What scale? Different normalizations will prioritize some differences between groups over others. <div style="text-align: center;"> <img src="figures/ecdf_log.png"/> </div> --- ## Dimensionality Reduction --- ### Multivariate Data One challenge of omics data is that each sample is associated with many features. This is often called multivariate data. ``` ## OTU Table: [130 taxa and 1151 samples] ## taxa are columns ## ASV97 ASV88 ASV65 ASV24 ASV109 ASV116 ASV111 ASV35 ASV49 ASV45 ASV41 ASV98 ASV31 ASV53 ASV6 ASV25 ASV121 ASV9 ASV39 ASV122 ASV28 ASV73 ASV43 ASV106 ASV105 ASV89 ASV17 ASV113 ASV64 ASV40 ASV72 ## Sample-1 18 82 1336 510 1230 40 33 38 363 257 116 6 71 225 72 185 17 176 81 15 102 223 244 143 3 467 67 19 189 248 44 ## Sample-2 1742 581 1121 303 425 445 233 253 456 164 209 377 99 209 127 129 298 108 110 170 80 148 195 56 55 352 32 73 79 169 171 ## Sample-3 15 1992 42 412 88 39 358 378 25 39 313 5 271 46 34 119 157 27 376 37 13 40 30 16 850 14 15 9 9 13 11 ## Sample-4 11 420 764 2015 2125 383 50 34 913 272 162 7 102 273 344 107 26 203 35 45 103 155 317 90 96 168 39 32 48 121 81 ## Sample-5 54 1028 980 54 2024 326 255 146 1977 172 274 9 137 388 50 142 513 232 48 119 67 252 250 129 41 734 8 37 125 318 91 ## Sample-6 12 167 299 1799 976 41 36 131 1210 239 194 9 27 267 57 28 18 166 15 16 21 84 85 18 15 55 329 25 13 63 12 ## Sample-7 10 62 20 960 2115 374 23 13 370 96 156 5 39 470 21 236 17 32 10 15 18 17 61 8 2 17 17 49 8 21 9 ## Sample-8 9 24 63 28 2246 189 55 101 376 128 589 3 31 861 9 166 16 1032 153 15 26 29 67 10 5 29 6 65 14 87 18 ## Sample-9 10 22 871 13 2304 58 21 17 72 57 656 3 96 455 9 24 17 35 42 16 67 19 45 20 148 38 6 114 103 14 9 ## Sample-10 10 147 2601 931 799 574 30 68 185 83 72 4 194 105 23 321 271 1309 53 20 19 92 23 163 15 131 29 21 30 128 33 ## Sample-11 14 287 804 40 836 819 80 206 86 69 590 3 410 145 12 27 45 659 242 31 17 39 25 22 6 33 7 31 10 34 11 ## Sample-12 9 106 5292 7 419 1546 65 175 57 49 177 3 62 116 12 285 41 673 40 15 28 18 22 527 2 31 14 405 7 81 17 ## Sample-13 15 120 1211 2348 635 66 49 63 303 215 184 8 89 363 208 367 19 114 59 16 77 92 266 88 70 115 201 47 118 99 25 ## Sample-14 889 41 1057 37 1133 75 37 198 1655 111 212 164 76 88 14 71 124 32 68 19 55 23 104 52 25 63 210 587 10 73 25 ## Sample-15 9 416 313 55 390 57 130 749 320 55 464 2 43 171 13 18 19 289 92 15 15 28 25 62 112 429 7 21 15 112 33 ## Sample-16 11 39 1693 1948 2423 68 19 17 834 53 183 6 145 288 45 126 18 1535 20 16 23 14 61 23 3 23 32 53 9 15 11 ## Sample-17 9 61 1474 35 408 938 235 1172 161 82 314 2 150 122 14 292 38 591 131 18 18 80 22 26 52 105 6 448 35 257 15 ## Sample-18 10 65 672 186 2537 32 45 31 199 83 350 3 52 270 15 121 17 473 71 16 23 34 26 84 60 19 23 35 16 60 13 ## Sample-19 10 147 1244 1930 842 155 173 222 398 80 185 6 112 91 92 44 26 333 156 19 24 63 39 122 398 26 18 14 70 193 18 ## Sample-20 19 733 3117 214 3568 607 253 654 1288 145 312 4 146 208 36 300 59 151 102 57 87 39 97 159 27 161 35 50 53 286 37 ## Sample-21 18 204 1185 56 1505 566 159 465 474 95 279 4 77 157 14 74 54 898 47 25 44 75 35 24 2 445 7 122 50 212 32 ## Sample-22 9 164 35 20 1434 106 299 435 287 96 56 3 358 242 9 21 17 496 662 19 21 98 34 14 861 41 6 11 37 169 14 ## Sample-23 10757 587 843 434 845 173 104 102 760 245 287 1398 89 289 317 93 20 34 130 18 175 35 234 89 62 353 111 236 53 100 38 ## Sample-24 90 711 1642 1598 1201 455 684 887 918 303 308 9 212 199 232 48 406 619 266 81 88 104 148 77 430 81 70 30 261 86 54 ## Sample-25 10816 502 1457 810 705 180 513 42 718 264 228 1498 285 268 86 69 33 831 24 21 88 102 251 76 48 97 40 27 191 115 88 ## Sample-26 11 160 1050 2394 855 24 50 41 540 219 172 7 251 212 282 16 18 200 98 22 100 76 111 31 80 121 197 273 19 48 16 ## Sample-27 2472 57 1417 136 139 316 44 51 24 65 54 451 108 61 69 645 21 39 31 24 84 40 51 60 10 41 15 20 20 39 45 ## Sample-28 8049 339 782 60 279 206 225 476 35 148 147 1553 128 91 27 330 65 20 75 50 43 44 48 39 18 52 14 33 9 45 41 ## Sample-29 162 218 2942 169 414 1173 212 137 57 118 131 29 286 96 30 686 17 100 91 155 129 149 73 352 81 39 12 97 48 99 88 ## Sample-30 33 49 160 18 355 567 171 237 118 52 387 7 104 178 11 1513 27 61 287 35 28 75 50 96 126 91 7 26 201 59 32 ## Sample-31 265 67 142 32 600 489 184 373 442 101 1221 51 172 291 41 486 32 66 199 79 70 191 55 58 121 94 8 861 22 71 33 ## Sample-32 331 1032 946 111 1030 3191 714 1650 437 252 537 67 195 650 28 524 28 145 259 290 84 273 189 53 156 204 110 92 26 298 57 ## Sample-33 48 199 103 2600 68 43 228 93 12 73 100 35 69 24 1086 22 36 29 29 19 22 16 17 88 21 15 215 10 7 10 10 ## Sample-34 19 2695 414 211 147 335 441 158 42 163 489 13 121 59 85 46 33 32 252 37 44 46 45 29 115 28 1993 30 24 20 54 ## Sample-35 16 165 2082 2918 93 45 64 71 27 815 101 19 154 36 94 28 20 27 36 16 36 40 56 34 11 59 119 130 429 59 28 ## Sample-36 17 23 24 1638 30 4483 410 354 8 80 29 8 47 15 37 20 18 14 24 17 13 16 13 36 3 10 184 9 4 5 7 ## Sample-37 384 609 454 1460 55 232 206 53 16 264 352 22 164 47 422 54 22 14 233 26 106 44 52 31 17 19 961 14 19 15 35 ## Sample-38 176 4864 284 1485 128 307 1198 307 27 295 332 18 560 60 411 28 475 64 89 74 173 43 64 165 76 23 91 34 19 36 512 ## Sample-39 336 24 342 109 684 355 28 229 474 398 391 54 93 323 25 245 16 67 24 15 173 58 145 21 15 107 16 1080 41 90 22 ## Sample-40 26 2034 1106 36 198 484 284 83 102 161 166 4 77 220 110 844 122 62 192 80 133 47 63 264 18 23 31 64 14 33 34 ## Sample-41 10 261 28 117 189 972 223 467 161 117 312 3 72 68 58 931 365 39 101 145 26 51 28 45 62 15 39 674 16 23 16 ## Sample-42 65 299 918 1094 328 250 123 82 185 102 252 11 345 137 444 776 63 50 143 154 105 35 160 97 211 54 108 76 123 39 162 ## Sample-43 8079 307 1470 624 334 144 83 45 105 147 106 1013 205 128 147 72 48 198 41 61 88 140 106 64 41 80 54 157 13 39 36 ## Sample-44 10 229 313 41 680 384 133 239 240 99 103 3 130 298 21 45 17 81 59 66 103 107 190 119 20 150 9 24 40 184 60 ## Sample-45 3528 67 2392 91 1213 559 123 1283 1080 388 246 578 337 496 20 152 17 155 39 17 155 289 273 71 2 236 15 74 283 147 196 ## Sample-46 47 88 1774 197 437 501 89 51 250 281 112 5 126 267 75 188 16 57 51 22 116 130 179 59 76 58 24 345 196 253 61 ## Sample-47 110 43 506 34 1395 1333 87 87 756 216 405 17 123 362 64 143 21 59 61 131 178 123 303 31 76 290 16 65 153 176 35 ## Sample-48 550 542 1970 27 1811 591 220 101 1048 451 293 94 277 489 46 13 122 149 39 107 227 138 386 60 39 833 9 25 133 351 262 ## Sample-49 626 138 2372 18 494 1843 70 51 154 459 105 82 272 262 14 649 54 46 59 26 255 136 365 265 25 103 8 25 48 247 65 ## Sample-50 38 1358 24 25 803 606 428 173 487 199 391 7 217 85 21 628 130 43 86 1353 47 172 42 16 9 52 7 9 11 47 87 ## Sample-51 12 57 36 22 150 1471 135 67 80 60 116 3 49 136 10 113 17 13 53 143 22 39 40 12 30 31 7 123 38 64 22 ## Sample-52 6762 832 645 82 540 850 798 1288 385 617 387 1242 231 460 19 342 157 108 151 135 141 339 211 70 158 115 11 60 81 388 226 ## Sample-53 36 50 26 10 433 75 43 41 228 42 115 7 39 129 11 60 321 20 24 751 20 20 28 10 18 46 6 14 7 14 15 ## Sample-54 283 467 1341 56 663 715 1327 168 389 388 344 90 150 289 54 211 29 248 69 32 155 156 237 208 47 97 17 21 186 226 97 ## Sample-55 10 54 530 87 1225 30 29 36 1078 409 151 3 256 372 57 57 19 110 47 14 60 214 208 40 64 124 39 19 145 297 125 ## Sample-56 27 2050 121 10 1020 1566 354 91 882 628 801 5 535 663 10 38 18 37 37 247 224 296 253 42 55 318 7 84 61 421 642 ## Sample-57 1960 1044 889 630 531 446 325 252 257 251 239 472 191 230 117 168 151 45 114 87 94 77 113 737 91 72 70 15 24 191 160 ## Sample-58 9 22 187 13 967 213 22 69 226 113 300 2 75 283 11 12 16 214 28 17 107 46 507 12 21 183 8 18 26 89 19 ## Sample-59 16 153 925 522 468 62 71 37 185 318 70 5 153 374 124 69 16 69 83 18 114 333 166 190 3 232 42 120 111 124 81 ## Sample-60 9582 520 254 53 461 132 480 1077 142 99 259 1419 191 431 24 151 149 17 92 256 91 92 75 28 63 114 13 54 22 144 48 ## Sample-61 39 4154 623 501 650 1912 1791 632 743 275 664 9 151 303 47 105 171 58 119 146 169 168 244 41 39 189 16 23 188 96 79 ## Sample-62 6119 106 925 96 853 2095 74 86 283 346 96 1114 380 196 19 525 30 83 54 19 250 23 90 56 32 63 10 22 143 35 502 ## Sample-63 17 1208 203 125 2320 295 1276 1349 663 3520 1310 4 181 816 25 20 18 244 138 53 554 98 1056 358 197 1062 10 731 71 293 185 ## Sample-64 18 335 2032 287 614 515 170 119 350 143 167 8 114 141 75 87 113 165 125 93 172 98 70 191 83 252 67 148 113 61 65 ## Sample-65 12 637 2368 133 948 1180 350 740 617 184 195 4 189 273 23 88 173 256 232 91 225 144 84 157 158 118 17 34 180 154 100 ## Sample-66 23 840 3936 1380 689 379 420 851 267 368 223 11 742 190 276 146 346 338 352 139 126 234 221 316 341 107 106 28 51 108 857 ## Sample-67 17 1826 1339 308 374 900 898 301 160 197 362 7 224 162 328 152 244 116 138 293 123 228 70 297 206 50 41 26 70 40 54 ## Sample-68 18 123 642 66 1138 538 61 80 271 150 141 12 376 144 111 200 61 172 28 30 224 80 170 46 190 179 16 85 240 104 288 ## Sample-69 96 542 519 102 992 1004 2650 1999 427 149 788 25 363 393 77 620 19 71 1030 96 94 35 97 312 668 53 22 279 28 173 33 ## Sample-70 16 521 2481 414 361 475 227 192 114 211 199 6 176 153 159 80 56 237 67 81 94 97 47 112 560 81 50 64 108 45 34 ## Sample-71 95 707 2747 962 872 310 345 217 551 606 188 67 571 208 134 109 760 616 236 221 167 303 150 226 229 260 33 80 335 97 185 ## Sample-72 26 60 2571 514 2713 1196 45 37 692 211 106 16 289 515 84 1226 17 787 36 23 198 101 133 266 8 89 51 72 21 55 57 ## Sample-73 12 1573 39 108 229 171 773 1594 55 112 304 5 175 137 124 108 740 67 587 134 19 58 49 38 401 56 73 15 138 39 19 ## Sample-74 46 545 3138 383 1058 793 195 130 415 340 202 78 198 159 54 241 252 398 59 85 388 257 179 295 175 110 50 173 160 122 69 ## Sample-75 11 71 1217 143 1438 467 129 117 380 167 62 4 257 199 57 525 272 389 138 16 202 110 64 26 109 128 65 32 265 150 130 ## Sample-76 43 630 186 69 2801 3185 316 722 505 135 477 10 233 307 27 165 455 123 79 148 121 206 71 132 7 158 11 18 302 43 43 ## Sample-77 43 2760 733 228 762 324 828 1209 643 261 374 10 143 160 63 1487 107 468 345 149 70 374 103 97 179 79 19 11 49 59 33 ## Sample-78 13 722 1787 208 268 1498 421 295 67 199 135 5 194 140 92 75 104 57 356 226 152 144 60 145 164 66 37 51 374 44 35 ## Sample-79 12 662 3053 802 637 538 245 88 335 295 168 7 374 225 211 796 77 291 76 161 237 232 250 454 35 86 105 165 158 51 145 ## Sample-80 39 389 1035 308 510 182 216 216 145 184 120 6 147 88 91 64 363 187 148 84 46 132 92 63 144 43 41 17 117 38 118 ## Sample-81 12 261 51 580 360 374 1307 765 552 317 565 5 367 105 81 110 291 84 1046 182 19 26 30 25 770 90 188 12 13 23 19 ## Sample-82 11 365 71 49 910 170 421 535 650 157 173 3 198 200 28 1231 16 331 392 218 38 417 44 29 213 54 10 138 38 99 33 ## Sample-83 5167 349 1118 675 543 199 123 397 154 274 153 795 387 200 97 15 18 179 94 47 314 119 65 25 9 179 39 28 15 57 309 ## Sample-84 756 361 2466 68 1404 734 203 227 181 239 212 175 529 207 77 55 251 198 66 222 184 196 68 105 151 420 25 32 409 86 336 ## Sample-85 16 46 2296 191 776 1604 31 352 145 393 98 9 178 238 35 61 19 128 26 17 246 404 126 118 119 108 49 31 249 68 35 ## Sample-86 72 287 187 37 785 1769 270 590 161 410 299 5 255 212 21 169 18 392 366 18 100 85 97 20 34 49 16 17 69 329 36 ## Sample-87 46 220 977 450 1091 624 177 627 661 152 125 23 249 213 70 243 66 319 187 40 101 100 82 159 266 230 28 27 37 62 146 ## Sample-88 408 3292 222 355 376 1081 954 487 132 105 609 89 211 483 176 443 88 163 613 82 39 144 133 58 185 130 19 78 42 119 39 ## Sample-89 12748 1102 1646 171 316 314 307 784 122 163 171 1826 159 132 27 101 122 54 74 66 59 49 64 117 91 64 21 131 113 33 78 ## Sample-90 15 433 2851 504 1435 842 323 258 876 515 354 6 167 287 100 125 19 268 348 18 234 48 184 62 266 37 31 18 213 20 41 ## Sample-91 12 154 3334 127 1419 683 69 48 259 133 178 4 234 192 42 542 18 143 100 19 165 73 136 178 88 53 18 30 45 77 50 ## Sample-92 149 590 368 145 1062 1108 467 647 434 171 317 33 133 241 29 580 1342 224 235 169 71 98 74 23 129 124 12 227 243 107 33 ## Sample-93 11 133 2275 40 650 1232 123 134 215 97 103 4 116 138 55 90 243 114 132 80 129 70 98 208 94 86 11 35 61 80 36 ## Sample-94 14 851 138 244 422 286 547 138 338 152 570 5 75 95 178 2178 23 135 274 260 24 31 35 33 119 179 65 271 51 99 19 ## Sample-95 14 114 1971 105 1980 876 301 232 912 352 311 5 232 248 53 274 20 140 284 24 281 136 90 60 175 176 13 430 205 161 41 ## Sample-96 10 99 2155 203 1357 778 212 140 319 134 177 3 301 201 39 210 58 156 270 60 226 53 128 81 273 372 29 28 119 131 51 ## Sample-97 11 46 1627 56 1124 275 210 191 372 236 136 3 419 148 17 373 84 637 210 19 207 129 65 92 142 145 9 280 222 223 116 ## Sample-98 19 2432 294 70 707 283 1628 698 258 761 787 13 332 208 45 136 16 226 611 129 212 87 149 53 216 152 19 22 20 57 40 ## Sample-99 24 475 4211 934 699 3033 518 172 279 290 197 8 294 180 370 213 249 195 251 444 262 191 118 365 249 192 129 61 229 155 205 ## Sample-100 16 217 2883 250 825 683 159 472 445 216 356 8 193 263 89 704 81 336 152 65 117 158 106 246 224 91 25 831 47 59 160 ## Sample-101 14 327 1239 300 1621 2662 441 1878 590 201 236 6 286 205 140 913 21 232 532 22 174 108 70 66 569 138 44 48 71 268 77 ## Sample-102 13 51 3368 145 2121 165 48 137 580 349 126 5 144 517 68 935 18 470 38 17 213 295 187 155 5 549 23 86 542 100 42 ## Sample-103 13 737 653 65 590 3978 193 324 391 137 210 4 82 280 36 529 22 157 72 24 49 59 58 718 511 47 31 40 91 33 24 ## Sample-104 791 4772 1428 222 958 640 1354 623 261 252 671 136 548 286 147 434 245 283 181 591 101 559 100 116 28 81 62 49 55 76 65 ## Sample-105 24 2128 210 1344 285 751 884 445 144 646 512 9 382 101 189 379 705 99 574 710 36 158 47 32 398 35 1076 237 44 20 16 ## Sample-106 102 1281 1380 412 828 726 760 757 934 586 436 24 175 347 202 265 434 197 181 365 202 144 305 105 181 88 143 15 37 168 122 ## Sample-107 18 711 1679 298 905 325 152 571 584 322 279 10 253 374 86 238 21 359 94 75 299 181 162 42 9 168 77 60 310 182 68 ## Sample-108 2067 875 1325 117 1299 430 964 402 719 576 521 391 133 401 50 313 72 332 99 308 166 386 407 66 57 465 15 28 86 148 209 ## Sample-109 19 1317 471 149 1296 982 776 264 125 244 461 5 244 241 96 36 462 264 118 602 159 262 74 39 19 63 20 40 49 151 70 ## Sample-110 43 1942 252 97 491 1871 1182 325 214 172 628 11 262 347 23 401 203 237 207 451 99 133 194 62 132 74 10 25 22 181 318 ## Sample-111 265 99 2559 280 2695 559 52 46 905 497 166 51 254 321 31 26 57 441 32 34 172 128 258 163 49 598 38 25 44 106 241 ## Sample-112 49 377 1677 244 481 1120 275 227 236 241 131 7 199 219 120 162 318 134 130 39 162 177 141 227 90 78 64 48 137 163 83 ## Sample-113 28 1085 2988 220 404 757 419 72 204 214 273 6 523 208 69 57 150 67 52 182 168 138 465 136 40 119 19 30 49 92 95 ## Sample-114 975 561 614 142 174 142 242 202 73 94 130 214 151 90 54 32 35 47 50 137 50 89 91 35 109 47 13 26 49 33 39 ## Sample-115 14 1282 1645 132 714 692 493 1126 422 225 242 5 290 272 32 147 96 63 145 311 79 395 190 52 148 73 23 16 55 116 63 ## Sample-116 11 974 3236 298 556 2388 218 107 372 256 182 4 322 300 127 179 51 56 153 112 173 170 109 139 211 146 22 116 67 87 92 ## Sample-117 15 1858 3487 768 269 326 507 132 136 163 214 7 165 93 42 93 99 48 82 589 168 70 109 160 24 60 47 20 23 38 60 ## Sample-118 14 1057 680 187 342 794 463 1089 207 386 243 5 593 204 102 96 414 72 60 275 254 319 177 45 42 168 31 35 132 129 162 ## Sample-119 20 900 560 66 1298 2109 1099 707 768 269 326 4 260 420 49 175 57 56 105 207 210 310 357 246 38 127 12 87 119 136 99 ## Sample-120 3563 2223 750 196 636 372 835 753 204 161 383 659 361 257 34 53 148 85 281 273 196 155 90 85 61 41 21 36 15 51 161 ## Sample-121 1146 2272 672 341 330 1793 1424 204 170 268 408 246 437 382 78 84 201 144 401 439 217 148 211 80 38 106 60 69 82 57 93 ## Sample-122 9557 531 2567 151 633 969 263 581 238 197 204 1382 350 151 66 109 119 127 157 282 136 139 141 239 36 136 18 16 69 97 161 ## Sample-123 22 1560 99 12 252 2258 1174 219 108 195 217 3 62 61 8 16 23 56 107 955 73 87 29 54 2 50 5 16 61 40 48 ## Sample-124 24 141 771 20 736 2057 180 119 187 94 258 4 119 184 15 1039 48 126 173 61 69 41 70 52 80 42 8 32 64 66 50 ## Sample-125 10 1748 1329 76 1484 1390 644 2529 1094 376 286 3 130 227 83 84 321 430 173 41 272 87 210 103 116 119 14 141 45 373 50 ## Sample-126 49 132 552 19 3607 1163 127 302 657 282 432 11 480 720 14 44 57 562 155 121 387 145 257 90 43 44 7 59 44 107 177 ## Sample-127 12 2044 3325 218 456 1720 600 113 244 315 319 4 567 222 87 139 259 77 230 701 334 270 181 335 73 40 29 267 141 38 127 ## Sample-128 16 2049 2290 72 951 2382 541 185 480 189 294 4 130 110 55 312 323 209 104 478 48 103 148 185 26 116 11 20 61 47 51 ## Sample-129 11 260 4852 585 1136 1501 270 196 438 227 169 9 265 332 154 290 100 253 266 206 257 206 267 259 393 212 70 54 648 319 102 ## Sample-130 37 1258 432 57 772 2360 1048 454 362 181 611 9 112 153 27 159 40 133 732 113 155 146 54 31 17 40 8 382 85 59 50 ## Sample-131 101 159 1470 26 2361 496 581 1233 1447 490 369 24 488 692 18 48 20 222 109 77 241 340 225 338 269 451 8 96 119 132 215 ## Sample-132 31 67 2269 15 1412 898 198 303 370 357 229 5 475 210 23 17 18 215 34 16 66 109 190 158 7 37 19 258 74 134 109 ## Sample-133 10586 941 2163 42 368 399 453 980 117 221 217 1821 395 181 23 58 239 59 219 118 63 192 86 129 196 87 12 20 37 71 93 ## Sample-134 25 207 221 198 2512 292 253 100 597 464 206 5 175 205 138 27 17 261 208 26 82 59 169 290 24 40 37 50 49 192 55 ## Sample-135 259 187 2604 45 2091 2685 240 1207 1813 884 544 31 389 538 74 88 39 557 179 54 656 79 286 361 217 99 12 77 24 124 514 ## Sample-136 13204 545 2152 135 602 639 345 1104 477 242 185 1877 250 232 211 338 127 63 206 257 144 217 114 130 267 108 26 220 81 82 109 ## Sample-137 1776 3260 3380 301 698 564 494 323 456 284 319 381 360 182 403 46 263 144 95 358 136 154 185 310 65 645 43 16 132 92 80 ## Sample-138 23 1665 2353 589 927 814 475 173 372 228 273 8 292 266 183 114 145 124 165 217 253 104 132 137 48 169 28 135 60 146 105 ## Sample-139 12 262 2667 2477 940 548 473 75 431 463 197 8 265 176 76 76 70 630 110 53 177 256 178 123 181 126 308 124 299 115 268 ## Sample-140 16 2403 1207 740 717 799 628 802 440 277 296 7 128 198 258 167 1374 101 160 329 96 177 137 102 38 70 203 77 133 91 46 ## Sample-141 85 533 1932 84 1467 1075 152 232 456 252 171 5 344 259 47 255 82 361 76 390 556 127 99 56 77 348 15 110 246 136 401 ## Sample-142 14 2001 1070 279 501 753 846 1387 470 205 383 11 509 180 203 28 19 221 298 266 110 244 190 207 395 84 23 25 53 96 57 ## Sample-143 30 385 1892 112 130 422 455 120 39 99 149 8 143 64 45 23 128 30 107 342 123 44 57 79 25 27 16 20 13 44 28 ## Sample-144 9 76 793 29 667 1479 165 50 561 282 163 3 149 207 11 44 81 114 96 46 247 86 150 74 99 107 7 32 63 175 57 ## Sample-145 10 533 2566 124 588 1026 836 116 140 557 341 4 570 313 37 184 315 126 290 172 425 201 191 144 21 80 13 45 119 85 309 ## Sample-146 11 3718 1125 890 868 231 791 81 345 139 306 5 118 122 249 43 121 52 106 404 59 142 115 142 94 139 34 16 28 72 43 ## Sample-147 22 182 4287 377 925 1115 77 73 386 261 155 5 201 254 67 95 80 368 104 47 277 202 263 558 204 113 38 42 444 129 94 ## Sample-148 6959 1253 1607 469 999 1662 890 506 609 291 372 1216 155 306 216 1241 63 154 196 164 156 166 184 190 136 117 64 101 88 71 38 ## Sample-149 12894 502 479 57 216 319 197 129 58 313 90 1815 219 113 16 18 106 34 56 42 117 72 99 39 16 66 12 32 28 30 85 ## Sample-150 13 135 1188 280 238 532 70 37 137 137 65 5 220 102 69 414 27 61 38 82 131 108 89 29 55 82 20 88 70 75 310 ## Sample-151 24 1757 854 451 353 156 259 157 141 211 182 10 95 119 52 183 41 97 57 25 141 79 85 46 26 60 73 17 13 24 31 ## Sample-152 7233 142 972 202 1396 592 157 78 132 131 83 979 116 228 19 124 77 135 65 47 128 129 152 71 50 98 16 81 44 75 40 ## Sample-153 186 1042 3083 170 424 680 1364 86 326 278 384 44 90 163 103 462 353 183 149 55 151 86 125 547 18 87 31 130 51 76 32 ## Sample-154 189 2338 679 99 448 173 729 555 124 157 399 43 83 160 37 546 20 107 261 94 152 111 90 43 95 156 60 202 60 44 23 ## Sample-155 22 427 378 26 1230 987 183 120 317 296 144 4 73 169 21 233 73 275 105 133 137 53 170 57 45 27 8 33 79 106 38 ## Sample-156 6424 1058 3679 101 339 339 404 257 300 231 137 1029 220 232 31 96 87 164 178 119 119 147 98 178 154 113 34 64 78 90 109 ## Sample-157 19 484 1057 48 334 1541 104 131 88 126 83 4 89 113 37 52 43 74 58 24 137 54 83 288 15 46 10 29 77 34 35 ## Sample-158 16 28 142 11 170 83 44 30 26 58 31 3 68 143 9 23 22 55 14 19 44 37 34 22 3 70 6 20 29 95 34 ## Sample-159 93 164 2430 279 1348 447 203 60 513 246 181 6 94 296 41 253 47 202 42 30 195 216 161 241 2 68 45 177 27 113 61 ## Sample-160 307 1281 2184 121 757 316 1537 514 426 308 429 59 234 246 73 135 117 138 168 118 166 413 179 123 244 108 16 266 42 154 155 ## Sample-161 3642 1190 2821 313 1085 942 654 388 916 247 204 658 338 390 203 258 493 131 499 89 135 159 319 141 607 202 41 54 196 174 142 ## Sample-162 1602 1239 966 145 1384 2524 1832 1503 572 418 363 318 188 583 90 149 24 255 378 180 133 461 218 126 344 107 30 31 68 294 45 ## Sample-163 69 399 133 115 1112 356 852 719 483 106 191 3 61 539 43 33 212 29 63 116 85 58 67 16 25 24 23 14 10 64 45 ## Sample-164 4738 2115 640 426 1165 947 1536 2042 710 255 463 878 248 376 183 389 78 87 424 56 83 188 178 150 485 64 35 24 34 311 116 ## Sample-165 32 472 482 14 1141 1691 457 171 408 194 378 4 285 509 17 70 17 82 412 160 117 176 102 41 75 122 7 42 18 1096 51 ## Sample-166 5101 875 2239 278 898 914 2056 247 529 299 351 880 292 350 105 143 440 66 205 218 136 459 126 465 219 423 29 50 192 199 208 ## Sample-167 1124 140 1261 748 1026 1319 130 93 322 232 206 196 260 333 41 23 88 351 59 127 316 238 388 126 52 122 27 32 124 127 193 ## Sample-168 17 208 1746 2598 952 490 157 667 679 504 152 8 245 320 134 162 39 462 97 30 180 313 352 90 155 174 52 121 206 285 166 ## Sample-169 989 2299 205 61 627 2795 809 104 382 490 418 175 369 397 14 434 404 110 165 305 529 270 96 39 65 263 9 218 1031 66 67 ## Sample-170 18 361 2492 991 738 687 208 49 315 282 162 7 145 243 144 101 39 220 84 265 310 99 166 229 81 159 35 125 39 236 67 ## Sample-171 278 74 979 64 312 1015 189 274 195 175 81 21 122 176 16 300 25 69 81 27 112 84 112 57 67 77 9 38 38 172 49 ## Sample-172 6913 145 1959 164 496 479 170 489 418 185 87 1020 163 131 81 239 45 142 104 64 112 166 154 77 234 110 22 22 114 141 161 ## Sample-173 233 506 166 75 835 398 152 213 205 187 202 35 296 395 46 169 60 94 94 276 198 269 392 28 45 186 10 160 30 306 82 ## Sample-174 211 79 541 47 455 309 264 321 139 375 240 36 127 331 21 21 16 116 129 70 81 173 176 26 178 104 10 375 285 180 62 ## Sample-175 453 260 1768 51 1348 965 241 94 872 291 314 77 165 591 48 471 60 173 113 133 158 208 216 94 74 310 13 176 513 193 104 ## Sample-176 24 1896 590 798 135 455 665 123 90 152 260 8 121 121 289 68 333 33 119 271 45 85 89 186 129 25 25 39 18 28 22 ## Sample-177 16 385 1027 71 929 1815 178 2248 420 207 118 16 143 253 23 130 43 69 132 27 194 227 169 32 39 80 10 49 111 307 52 ## Sample-178 11083 947 3454 684 657 733 329 216 614 374 260 1814 366 448 203 67 162 375 186 99 253 214 112 273 182 167 74 75 162 82 220 ## Sample-179 529 4701 2431 230 890 1753 1823 2117 430 412 724 119 146 184 183 765 19 105 527 192 254 182 135 413 165 58 18 39 293 61 102 ## Sample-180 16 675 3410 424 995 1307 444 358 450 369 430 5 434 395 172 515 109 257 542 282 303 169 154 108 111 205 32 264 249 113 233 ## Sample-181 16 362 4194 1013 785 1907 218 210 262 272 192 7 230 251 170 306 211 120 142 242 323 181 177 787 203 169 42 35 143 59 56 ## Sample-182 2882 418 595 225 424 136 85 93 128 106 117 532 204 64 143 20 99 49 66 78 38 52 45 36 23 30 20 36 11 27 228 ## Sample-183 25 1061 747 130 553 1963 590 893 127 133 277 9 158 141 170 994 130 122 352 218 207 98 95 174 149 93 26 34 168 52 46 ## Sample-184 13 3613 1589 649 525 219 766 653 410 216 260 6 192 111 178 178 217 115 341 392 209 165 58 165 296 77 18 56 201 26 39 ## Sample-185 173 659 316 116 820 523 335 732 1093 243 518 72 95 317 65 1615 62 170 127 153 73 186 164 24 37 63 27 863 66 123 32 ## Sample-186 14 911 234 38 958 2911 2234 3433 402 230 591 5 168 260 40 98 77 139 589 449 285 183 124 873 183 39 11 60 80 135 58 ## Sample-187 47 2357 1865 146 868 2182 603 669 499 256 346 25 430 336 139 222 124 341 397 116 205 164 205 146 62 70 38 25 38 240 55 ## Sample-188 2363 341 3103 192 1070 810 290 76 411 387 283 345 257 344 30 39 57 263 104 47 292 158 183 216 127 124 29 543 61 199 128 ## Sample-189 37 608 1947 271 675 1215 724 274 301 218 272 6 128 197 117 55 562 107 258 175 140 334 71 137 165 98 38 276 164 223 49 ## Sample-190 13676 601 1991 200 597 292 424 134 369 255 163 1943 146 245 31 50 85 107 50 73 108 245 115 119 79 116 40 51 71 136 183 ## Sample-191 1067 2361 1009 389 409 135 695 654 111 165 259 132 167 170 69 23 241 47 246 195 263 93 120 68 20 129 29 20 67 46 70 ## Sample-192 23 1408 412 65 336 756 1193 436 106 151 317 4 75 100 88 237 227 91 174 281 73 159 109 32 134 43 10 18 38 108 41 ## Sample-193 11669 293 914 181 174 264 328 103 76 154 119 1604 237 134 133 102 63 58 54 56 166 139 103 44 10 96 39 51 310 59 227 ## Sample-194 14 761 113 21 110 118 388 912 14 76 107 3 24 32 13 35 18 28 114 32 20 33 44 44 88 13 8 12 11 14 12 ## Sample-195 23 964 1852 292 575 1540 606 848 549 508 283 7 152 247 164 99 559 198 215 127 167 375 204 60 206 63 40 129 204 114 139 ## Sample-196 1434 118 1690 292 1207 105 77 75 473 387 120 234 191 263 59 41 96 347 79 52 182 171 207 83 113 81 38 24 64 146 116 ## Sample-197 651 423 1220 63 262 811 189 80 145 138 373 106 225 165 38 126 464 43 48 106 108 102 148 44 41 53 8 1099 62 69 423 ## Sample-198 11 365 1444 32 736 1670 468 137 576 257 199 3 186 326 25 112 651 189 140 131 111 236 181 90 171 172 14 89 169 394 71 ## Sample-199 13 590 1507 2899 336 1393 124 81 167 369 110 7 520 226 89 78 224 64 97 39 195 123 120 106 68 34 72 30 146 53 276 ## Sample-200 5142 974 1282 220 599 902 563 580 297 311 162 812 212 272 143 108 173 254 165 125 113 232 143 97 123 85 25 27 125 174 135 ## Sample-201 614 367 1764 55 647 612 218 2548 262 201 141 115 349 219 29 77 75 91 172 203 193 85 161 157 45 68 12 110 29 125 336 ## Sample-202 15 1161 635 89 883 1940 1098 907 592 259 319 4 139 326 23 56 127 205 237 169 118 285 224 80 181 91 11 89 84 253 73 ## Sample-203 665 337 1097 92 808 1732 101 1695 290 324 648 114 211 185 78 42 33 74 102 48 358 223 109 99 102 82 11 1334 86 380 61 ## Sample-204 16 348 1323 929 493 742 439 80 203 183 183 6 114 159 91 1290 178 190 75 223 116 129 139 266 189 127 18 32 72 54 31 ## Sample-205 39 1488 434 19 658 2294 619 3161 174 217 276 8 127 157 14 547 63 62 270 121 98 124 68 420 83 45 7 94 31 128 48 ## Sample-206 431 149 2437 185 1271 1958 336 258 725 366 317 87 538 416 50 288 27 335 235 94 287 179 166 107 103 273 15 370 75 265 395 ## Sample-207 11 1560 456 576 440 324 465 425 389 276 273 5 130 292 161 95 331 88 102 202 165 152 277 41 96 98 29 338 220 146 58 ## Sample-208 15 1151 219 190 613 1807 668 204 173 81 263 5 124 188 39 77 160 43 98 418 87 173 117 32 37 56 22 28 29 35 36 ## Sample-209 12 1234 1430 82 738 539 1183 244 390 188 374 3 180 262 32 27 54 166 254 223 120 447 169 138 171 83 11 57 78 205 88 ## Sample-210 13 2075 2294 202 271 688 786 228 157 288 287 4 139 79 59 23 513 46 190 252 64 148 61 202 137 50 34 68 14 34 42 ## Sample-211 17 606 2375 778 359 776 245 130 257 380 135 9 164 214 76 117 52 87 60 163 157 215 198 434 53 115 56 114 108 89 109 ## Sample-212 34 1788 884 333 420 558 1203 908 239 197 478 8 97 208 119 23 85 56 400 344 86 131 96 344 191 56 93 421 9 61 49 ## Sample-213 260 2313 909 570 483 189 774 343 69 99 249 16 110 86 557 440 260 62 264 421 148 74 33 64 179 36 69 55 26 68 25 ## Sample-214 8641 590 810 661 106 163 117 568 37 73 106 1283 87 64 236 43 140 25 66 56 69 33 34 55 33 22 38 15 31 12 19 ## Sample-215 73 1197 1574 1345 1140 336 570 411 445 120 307 16 177 415 421 193 22 180 691 78 169 51 103 223 469 81 58 74 290 22 25 ## Sample-216 21 1790 1355 1753 362 881 364 194 69 129 374 15 373 172 228 178 205 68 300 96 191 94 77 89 229 41 92 164 55 54 78 ## Sample-217 11 122 2250 239 515 567 84 195 667 95 93 4 92 99 41 24 18 167 41 22 76 69 75 121 10 71 31 24 16 74 29 ## Sample-218 10 57 1280 225 319 413 113 85 118 83 110 4 87 86 48 74 122 90 106 22 62 102 62 73 173 70 26 71 75 17 36 ## Sample-219 1060 1834 1041 145 766 1796 618 871 528 219 461 225 238 540 680 2041 3986 110 490 170 127 158 123 46 146 75 112 202 59 313 46 ## Sample-220 112 202 1944 532 966 1322 429 1227 494 232 194 6 211 293 90 86 34 125 471 34 176 276 230 285 448 137 38 21 388 91 50 ## Sample-221 12 385 1040 266 508 1294 221 374 449 205 291 4 158 137 66 68 142 124 208 82 127 152 118 87 132 233 49 348 29 181 39 ## Sample-222 14 287 175 59 556 2393 754 674 194 102 298 5 184 205 34 1334 240 52 1011 143 40 66 35 86 598 43 42 114 104 46 25 ## Sample-223 10 63 874 40 497 22 47 26 48 176 143 3 153 75 28 27 17 154 55 15 105 12 23 112 3 12 238 58 30 8 165 ## Sample-224 13 347 2120 33 925 130 103 34 179 420 87 4 118 156 540 186 17 266 49 16 142 48 94 71 13 102 685 26 451 57 29 ## Sample-225 12 117 2367 347 1504 114 135 141 439 92 95 4 214 269 24 79 20 320 350 18 501 217 89 155 205 171 168 48 174 188 43 ## Sample-226 62 188 1009 246 173 552 100 117 76 76 49 4 208 61 71 23 122 39 49 74 63 109 33 115 74 26 26 11 8 16 109 ## Sample-227 13 111 812 311 697 160 47 33 372 123 260 4 335 211 92 39 21 173 42 20 221 218 70 55 6 111 47 111 108 69 163 ## Sample-228 11 343 1238 43 257 513 264 214 99 91 189 3 125 146 21 100 113 107 134 102 90 81 49 152 43 88 10 66 28 38 54 ## Sample-229 26 180 1263 26 355 2075 248 345 114 116 121 6 127 136 18 89 19 52 172 93 131 71 62 617 85 67 8 13 147 63 67 ## Sample-230 21 1255 3243 903 858 676 441 1544 311 232 238 6 321 258 198 213 57 273 454 428 203 180 242 160 226 77 73 40 259 147 163 ## Sample-231 11 53 156 17 385 1300 309 738 123 52 111 3 134 107 12 88 34 72 447 41 41 47 46 49 387 63 8 122 22 31 32 ## Sample-232 13 130 1299 82 568 415 80 39 166 141 117 4 66 159 41 52 23 262 61 39 94 154 100 33 7 358 12 39 153 23 22 ## Sample-233 13 1440 3645 356 1068 828 578 231 333 236 316 4 300 261 149 62 267 376 399 26 167 297 122 484 226 129 71 145 54 74 153 ## Sample-234 24 259 503 37 1114 536 117 160 347 288 383 4 337 419 14 157 23 256 168 75 217 194 151 99 4 355 11 385 33 622 73 ## Sample-235 12 240 1067 66 1044 333 69 99 423 168 174 8 342 351 73 115 20 257 68 31 122 357 67 107 2 64 12 201 16 165 68 ## Sample-236 16 65 1146 1179 1313 486 151 928 152 127 189 7 283 174 81 139 19 146 347 18 30 45 112 23 81 60 171 206 410 42 128 ## Sample-237 11 1362 887 203 834 1969 1290 1054 167 146 360 4 213 237 328 87 17 107 501 122 87 499 179 101 70 38 46 39 39 102 40 ## Sample-238 13 55 578 79 967 291 40 32 191 188 216 3 242 179 42 64 19 143 40 33 43 86 156 33 1 67 20 17 150 217 40 ## Sample-239 592 1121 1708 65 205 452 348 229 159 180 174 92 160 125 23 24 23 114 62 305 45 66 60 110 58 43 18 12 12 38 50 ## Sample-240 23 3558 2104 359 331 1038 1128 555 95 377 503 7 390 202 139 67 26 85 1538 479 310 135 138 418 47 74 26 80 33 81 73 ## Sample-241 2665 160 2125 349 322 1757 116 27 119 154 79 511 178 96 135 130 32 61 43 75 105 54 57 167 97 80 73 20 16 39 36 ## Sample-242 9 195 2382 85 1671 655 75 31 290 260 202 4 181 271 187 66 95 116 36 43 81 146 185 205 4 182 101 27 490 239 32 ## Sample-243 9 60 1496 508 383 488 117 95 301 201 158 3 313 222 32 113 16 248 160 15 75 198 371 279 101 69 24 87 32 185 177 ## Sample-244 9 27 785 39 1451 266 141 131 1090 192 36 3 168 368 16 370 15 334 220 14 143 131 157 10 386 209 14 27 136 190 27 ## Sample-245 12 124 2559 926 972 618 95 37 910 208 106 5 205 285 38 236 16 355 36 203 120 142 136 513 179 200 66 158 139 278 35 ## Sample-246 12 94 2221 1868 1150 1097 228 242 955 240 202 8 223 680 230 369 29 90 381 98 106 34 118 57 486 124 77 70 178 187 64 ## Sample-247 678 359 2720 1047 939 707 209 285 535 300 118 145 183 246 58 1605 505 307 48 318 153 433 170 199 341 129 31 45 199 126 111 ## Sample-248 26 388 336 432 154 167 157 117 187 140 264 12 73 75 283 294 86 102 120 72 41 145 57 34 100 66 39 21 160 43 23 ## Sample-249 16 340 1682 636 1149 251 131 59 1071 309 206 8 572 217 132 185 76 214 264 90 247 190 124 120 23 355 87 55 247 155 65 ## Sample-250 11197 147 1098 91 441 84 46 106 187 215 64 1746 136 212 16 307 38 146 20 36 109 144 107 40 13 158 26 46 27 122 43 ## Sample-251 13 47 1561 646 1249 62 32 16 1071 384 35 5 149 282 148 214 39 307 15 17 311 168 140 139 2 465 66 17 208 52 151 ## Sample-252 14 304 1617 387 1045 662 224 140 435 251 242 5 147 170 94 547 432 218 258 94 376 203 63 179 49 82 21 303 220 68 41 ## Sample-253 13 60 2105 25 742 388 215 87 156 142 146 4 91 123 49 326 48 301 159 21 134 99 152 172 32 417 49 27 39 30 65 ## Sample-254 48 318 2034 881 916 467 137 47 527 318 143 15 280 160 142 15 57 463 33 48 163 106 171 470 41 278 42 224 19 134 49 ## Sample-255 14 760 335 21 667 595 806 980 317 177 227 4 82 131 12 92 1860 76 534 381 92 87 178 172 235 43 7 32 38 112 19 ## Sample-256 44 256 2587 1226 1106 338 118 87 606 281 228 18 297 187 209 22 55 347 32 31 285 266 154 670 118 371 46 403 33 143 96 ## Sample-257 31 1009 4102 1026 1162 648 383 189 681 356 232 13 596 198 240 21 234 367 167 136 297 149 228 710 155 542 45 47 45 103 111 ## Sample-258 22 851 3330 674 1110 509 373 202 619 317 219 9 561 180 180 19 210 371 188 116 246 151 195 739 141 489 36 50 43 110 101 ## Sample-259 12 525 1984 323 800 402 211 104 543 475 117 5 246 241 85 102 736 404 107 277 286 195 172 183 60 102 37 86 197 183 126 ## Sample-260 15 64 2387 42 1039 570 183 57 121 297 159 5 80 117 117 113 41 686 123 23 215 137 112 184 26 513 10 33 53 25 116 ## Sample-261 12 187 2411 1383 639 640 124 83 645 124 140 7 122 193 120 40 52 109 168 43 261 83 127 107 159 41 75 36 148 136 45 ## Sample-262 281 288 3412 2990 1037 400 232 116 535 649 145 13 393 252 197 25 504 520 118 25 559 274 207 219 212 210 294 64 239 126 312 ## Sample-263 234 225 2614 3046 1547 324 160 77 920 451 138 13 234 255 183 31 449 594 64 21 416 255 230 186 177 254 264 88 187 158 185 ## Sample-264 13 200 2372 73 1108 775 177 1507 995 648 387 3 140 266 23 50 17 157 69 19 166 146 300 253 3 398 12 606 368 194 53 ## Sample-265 17 622 1247 689 766 283 375 229 323 304 204 7 146 157 223 468 311 244 197 118 187 251 59 140 29 71 30 56 148 50 57 ## Sample-266 11 24 2181 21 1151 677 48 35 152 265 114 3 86 130 36 122 25 699 57 17 264 164 152 149 14 644 7 26 54 23 110 ## Sample-267 12 41 2399 17 870 637 180 87 131 216 172 4 106 126 40 193 38 456 209 19 180 95 137 184 50 377 8 84 44 25 69 ## Sample-268 25 457 1274 906 1317 660 646 108 431 367 483 11 221 133 167 58 40 360 62 65 105 50 79 159 35 203 39 368 23 87 75 ## Sample-269 40 279 2025 1045 1014 1453 235 188 589 451 313 13 235 166 167 173 73 571 80 70 210 82 175 285 52 193 44 304 30 77 127 ## Sample-270 27 286 1584 1292 1716 1143 229 81 433 405 309 11 354 193 230 65 50 511 43 86 145 71 98 292 146 219 37 290 26 81 103 ## Sample-271 467 976 206 220 1017 234 842 204 244 260 263 80 88 173 119 65 860 164 80 31 72 58 95 18 27 50 24 75 22 102 31 ## Sample-272 26 88 1522 345 2429 862 69 99 2186 592 261 5 118 450 31 95 24 529 28 22 52 41 216 69 4 48 38 807 54 50 67 ## Sample-273 12 48 2549 64 1871 450 115 45 665 181 145 4 156 305 29 93 64 810 68 19 229 103 511 218 62 852 123 161 208 76 86 ## Sample-274 4498 351 1921 147 1461 347 176 656 717 297 331 698 187 311 147 28 162 331 85 139 195 134 123 67 143 111 19 186 179 177 54 ## Sample-275 529 30 828 24 295 39 21 25 156 115 81 97 44 101 12 33 17 29 9 16 68 51 43 33 2 76 13 15 46 33 18 ## Sample-276 14 1450 531 113 324 392 218 152 108 197 223 4 210 175 41 169 130 114 103 74 99 82 120 190 25 238 16 65 94 95 177 ## Sample-277 13 584 967 160 406 536 145 149 200 230 153 5 85 163 55 63 43 146 149 39 83 69 84 163 34 220 21 56 148 68 67 ## Sample-278 13 184 1390 679 240 271 73 47 106 172 63 6 112 93 95 82 164 176 37 66 74 93 59 92 12 40 38 28 99 64 35 ## Sample-279 28 852 1144 266 721 530 551 330 631 212 208 5 129 263 52 463 353 241 172 430 70 247 127 48 216 76 14 83 30 147 47 ## Sample-280 7514 284 2700 182 537 430 153 120 401 219 188 1159 162 274 55 40 74 124 30 77 164 183 138 107 35 152 17 48 298 94 106 ## Sample-281 33 19 1544 2418 340 160 20 17 78 336 54 10 395 163 22 1362 19 145 10 17 105 248 101 118 2 88 50 71 55 35 90 ## Sample-282 58 18 287 64 69 18 16 12 15 42 24 16 26 28 15 443 17 44 8 16 21 33 28 15 2 25 13 31 10 9 8 ## Sample-283 2510 19 109 14 47 56 16 14 16 27 20 512 18 26 11 1007 19 20 8 16 16 16 16 11 4 12 7 25 10 6 12 ## Sample-284 3934 2039 2863 617 1718 420 1001 892 604 493 727 528 797 547 151 155 329 405 862 171 257 103 106 355 588 409 51 40 110 101 346 ## Sample-285 10296 28 1167 108 299 109 25 26 99 95 34 1596 47 79 13 345 20 123 13 20 96 59 57 39 9 36 16 29 125 22 15 ## Sample-286 2830 230 1096 243 387 174 160 148 139 304 104 444 464 144 110 1134 268 550 180 92 237 93 86 70 192 51 56 55 42 42 208 ## Sample-287 3885 112 1953 64 358 377 130 263 70 149 97 509 101 138 34 272 59 26 173 35 93 69 51 62 131 40 33 109 17 33 23 ## Sample-288 26 31 44 17 182 14 50 16 16 34 99 6 22 39 9 29 16 40 11 15 112 9 16 8 3 10 7 7 3 4 6 ## Sample-289 50 61 3386 917 471 382 31 21 100 196 109 13 87 168 123 2700 19 325 21 31 287 120 249 132 6 75 52 43 43 64 35 ## Sample-290 11385 554 2562 542 735 734 210 111 223 396 207 1414 563 230 224 351 387 140 185 71 204 142 142 316 132 124 79 37 326 104 292 ## Sample-291 4759 27 813 199 119 250 25 15 41 97 42 654 49 53 14 123 39 41 10 17 50 35 48 52 16 31 11 19 6 12 19 ## Sample-292 7691 297 1236 120 431 371 172 172 74 125 88 1497 114 128 111 127 1024 127 167 79 84 98 66 191 389 63 33 33 204 35 44 ## Sample-293 232 19 74 11 49 21 18 17 13 28 35 25 17 23 12 545 21 33 9 19 17 13 18 12 6 14 10 27 4 7 8 ## Sample-294 6541 469 1047 174 614 582 241 274 170 191 165 1279 479 248 120 189 62 250 259 62 204 79 58 70 91 84 32 21 122 42 172 ## Sample-295 17 130 768 34 631 49 494 317 49 105 50 5 184 32 22 151 22 45 676 92 36 36 35 115 541 27 10 21 17 18 26 ## Sample-296 27 56 2185 909 862 387 24 19 149 179 63 9 122 251 29 763 32 110 13 21 115 114 145 99 3 120 33 63 183 92 43 ## Sample-297 67 28 876 71 267 53 32 47 54 47 31 6 34 38 17 245 48 31 23 22 62 23 24 37 9 28 29 25 132 14 12 ## Sample-298 13 188 643 60 630 690 126 294 85 140 91 4 81 50 45 562 212 411 198 40 57 265 46 1009 240 42 11 49 25 20 54 ## Sample-299 253 38 124 55 161 92 34 26 25 48 42 55 58 26 18 48 33 26 16 27 21 33 17 80 138 21 18 12 26 8 27 ## Sample-300 44 115 4294 390 679 834 140 322 162 221 222 21 185 302 70 1012 158 450 170 38 278 263 282 191 165 102 64 108 101 56 188 ## Sample-301 7917 222 1753 232 340 557 99 103 115 120 132 1206 105 145 66 155 213 271 76 43 87 99 58 155 79 54 24 190 15 34 48 ## Sample-302 309 24 1139 121 398 367 35 26 53 89 71 65 56 97 55 1155 53 524 16 18 91 49 90 49 7 53 62 106 306 44 27 ## Sample-303 4502 218 869 207 234 165 140 97 64 96 71 783 111 80 31 86 271 164 66 77 61 54 40 89 86 27 24 16 21 24 122 ## Sample-304 8482 480 3962 444 1159 1178 205 318 579 353 288 1224 374 486 309 160 265 352 91 137 397 147 152 232 547 198 63 124 539 78 332 ## Sample-305 126 161 3208 1398 470 509 52 24 62 142 88 31 86 110 119 503 94 171 27 41 181 104 88 205 5 99 126 58 184 37 27 ## Sample-306 40 149 3542 1737 534 357 143 109 84 183 106 15 85 125 177 1431 27 145 163 41 135 113 108 81 81 127 214 65 89 70 42 ## Sample-307 1314 134 122 37 139 84 49 63 29 43 77 222 38 32 19 565 55 40 21 34 19 25 23 22 6 25 8 9 18 9 14 ## Sample-308 2692 109 1255 88 241 276 83 156 129 98 76 344 83 93 19 335 32 71 60 41 48 47 37 76 117 45 14 12 56 17 27 ## Sample-309 10199 319 3085 1052 930 575 170 250 437 305 168 2051 229 201 57 2223 374 417 47 231 137 345 130 500 336 97 38 19 144 80 126 ## Sample-310 44 697 607 819 1920 3244 1055 558 535 182 446 11 516 435 196 1101 187 391 1063 255 216 295 112 377 430 125 90 427 55 128 104 ## Sample-311 10 70 1655 392 600 351 258 67 496 145 64 4 80 155 28 571 17 266 167 21 131 90 148 160 186 70 15 18 27 79 19 ## Sample-312 12 70 1436 426 664 426 166 249 279 168 217 5 172 206 145 870 19 146 286 19 131 39 189 72 236 143 11 56 342 34 30 ## Sample-313 13 131 638 529 681 327 973 342 280 113 201 7 192 157 126 488 230 124 152 87 90 76 91 208 143 54 66 54 75 91 125 ## Sample-314 10 260 815 698 1066 762 110 84 1026 92 282 4 138 234 104 441 156 266 27 23 139 110 84 85 515 150 39 476 95 75 42 ## Sample-315 651 58 323 31 2173 94 213 380 899 162 604 116 149 561 15 178 26 148 273 30 144 85 299 128 213 241 9 1276 254 237 74 ## Sample-316 11 358 801 542 1144 1009 309 183 502 107 582 4 137 189 31 78 18 99 446 17 43 41 146 72 410 56 28 1275 81 104 33 ## Sample-317 13 19 151 40 1670 145 42 221 386 93 80 3 75 204 10 315 21 563 14 16 52 106 333 41 928 87 8 32 277 66 34 ## Sample-318 740 90 245 10 2477 113 257 1053 1542 234 183 137 111 898 11 739 19 172 35 35 111 219 183 61 79 397 7 90 33 188 139 ## Sample-319 60 53 45 32 1408 276 39 96 3415 252 53 12 35 141 13 24 19 54 102 17 18 18 33 30 2 24 11 43 9 8 8 ## Sample-320 11 69 182 9 2087 96 57 197 432 120 174 3 140 568 9 70 57 91 35 33 68 148 110 199 59 435 6 298 87 296 56 ## Sample-321 49 121 282 33 2267 629 66 224 1169 122 664 11 84 339 14 598 22 149 38 21 114 283 187 76 87 317 10 1613 400 65 28 ## Sample-322 14 2468 142 25 837 2072 594 411 1350 259 1126 4 122 158 22 403 85 97 824 633 134 205 126 58 352 152 10 515 37 36 24 ## Sample-323 15 50 115 11 1233 130 422 956 542 103 431 4 159 562 12 579 28 264 637 28 56 205 105 20 597 221 8 490 290 100 33 ## Sample-324 13 861 174 35 963 740 1036 1096 892 486 399 4 297 474 29 159 188 144 894 181 98 498 202 22 840 223 10 84 165 322 78 ## Sample-325 19 695 148 15 1506 459 158 949 1679 143 448 4 120 261 33 146 17 483 119 26 163 222 73 266 3 39 22 953 87 203 38 ## Sample-326 12 71 51 16 2753 215 441 615 2270 200 1830 3 286 780 11 106 20 208 732 49 198 560 287 139 871 468 7 1617 54 169 62 ## Sample-327 13 24 103 45 3268 23 51 337 353 132 210 4 83 775 12 201 20 184 105 20 65 204 247 19 93 50 10 457 72 43 39 ## Sample-328 177 585 629 79 669 1204 566 644 272 233 447 41 219 319 26 1180 41 88 1094 293 193 217 364 56 494 194 15 24 150 288 102 ## Sample-329 12 42 740 36 1017 531 48 241 633 127 548 3 110 511 15 1697 19 156 131 31 138 261 227 162 79 70 8 397 190 33 43 ## Sample-330 14 340 515 16 1647 726 787 1256 550 171 286 4 240 325 14 492 28 150 1202 74 185 517 299 401 984 217 8 64 142 63 81 ## Sample-331 11 82 151 23 1919 337 541 1193 1402 176 1299 3 235 335 13 116 95 248 711 26 179 158 86 295 681 92 7 2076 17 70 34 ## Sample-332 45 103 534 47 1690 215 87 380 1308 204 258 4 208 750 20 273 26 627 34 30 134 199 597 141 57 394 11 73 127 199 145 ## Sample-333 1405 56 463 52 1621 313 645 944 772 173 676 248 148 621 22 189 22 52 242 24 121 78 146 29 155 346 9 1518 26 189 50 ## Sample-334 17 218 758 524 3520 42 52 952 2139 335 413 5 251 504 127 290 20 563 111 22 155 33 165 25 13 464 46 718 65 207 52 ## Sample-335 16 472 445 19 1967 1047 899 673 601 626 482 3 366 316 12 435 19 36 872 88 100 290 48 188 511 73 7 60 43 50 44 ## Sample-336 13 280 154 24 1033 132 411 895 193 97 1078 3 263 326 16 530 33 826 584 94 73 132 69 23 243 554 7 44 652 105 90 ## Sample-337 345 927 256 141 315 431 476 95 178 287 137 60 66 198 48 171 25 87 54 74 90 97 99 247 40 61 12 154 191 147 30 ## Sample-338 15 423 2036 1164 257 448 178 107 150 265 104 8 222 241 284 569 61 77 106 141 160 140 148 255 126 92 48 120 242 168 155 ## Sample-339 19 498 2047 1203 847 564 175 224 524 200 156 5 392 307 132 72 72 88 74 54 222 168 141 362 252 73 89 300 29 152 347 ## Sample-340 1699 1607 1037 1129 849 640 433 361 515 279 269 279 236 613 137 280 57 72 138 141 244 265 235 137 52 516 107 187 388 238 221 ## Sample-341 18 172 1426 1770 2298 60 55 23 537 743 425 6 428 942 74 94 18 206 41 17 314 402 450 105 3 372 53 887 169 353 67 ## Sample-342 11 416 2463 1930 480 1042 232 54 262 227 103 7 103 282 170 636 152 241 200 37 265 39 242 418 10 176 95 100 200 43 35 ## Sample-343 30 353 1947 1253 319 402 62 56 320 182 76 42 258 138 90 385 34 79 36 178 141 179 106 96 13 81 51 54 80 50 37 ## Sample-344 326 221 818 191 278 65 151 96 151 165 92 53 62 196 29 135 17 47 27 103 114 99 173 252 5 101 65 46 28 214 35 ## Sample-345 39 1099 278 60 239 715 329 2460 103 75 328 7 51 130 85 393 1020 19 88 456 30 41 92 54 56 28 150 121 8 28 18 ## Sample-346 13 46 238 645 260 160 23 36 120 132 49 4 45 143 63 685 18 87 11 17 80 125 105 26 1 100 31 35 56 264 20 ## Sample-347 1118 146 766 46 615 26 38 178 1285 280 495 185 32 136 60 51 15 62 63 15 160 14 83 16 2 22 46 198 39 10 8 ## Sample-348 8567 165 778 200 369 816 118 674 77 321 80 1288 105 173 117 154 16 42 60 32 117 107 212 60 38 66 40 47 128 147 28 ## Sample-349 19 655 427 232 504 1157 142 72 207 341 138 4 93 158 22 304 17 83 93 29 106 169 90 903 73 57 24 155 47 120 34 ## Sample-350 12 504 399 1395 862 471 97 138 353 142 99 7 88 193 179 193 25 175 116 39 116 164 143 146 13 63 92 83 99 196 38 ## Sample-351 213 121 57 3493 1091 1083 20 16 226 912 66 38 35 392 38 474 16 127 11 14 26 61 376 12 10 56 37 13 19 40 15 ## Sample-352 5996 159 294 100 574 1061 266 491 260 362 110 1049 241 456 27 151 67 36 66 29 326 206 194 31 21 96 20 39 34 228 209 ## Sample-353 17 272 21 3014 51 23 25 23 15 102 54 8 15 25 49 16 19 15 12 17 12 20 18 9 2 22 43 9 5 6 9 ## Sample-354 30 1023 253 4000 257 67 100 52 144 187 97 39 430 76 829 24 32 153 42 17 104 147 81 53 78 102 204 10 53 33 282 ## Sample-355 7029 677 273 3649 109 47 57 27 45 87 51 1507 87 46 140 15 18 26 32 25 32 55 49 31 34 43 246 10 37 20 21 ## Sample-356 26 1967 485 2110 275 179 158 124 54 249 155 17 381 126 1232 33 50 78 67 568 67 125 159 71 139 60 628 21 41 58 28 ## Sample-357 18 424 2803 1777 204 95 38 20 90 417 47 18 86 73 79 233 50 162 15 19 73 406 115 253 77 140 443 57 837 51 41 ## Sample-358 126 506 358 7609 269 125 59 35 267 128 180 261 358 109 312 41 21 20 48 18 57 19 65 21 61 29 869 28 83 16 17 ## Sample-359 25 2969 1296 2760 120 198 561 89 42 110 206 27 52 70 839 60 171 57 72 92 39 83 47 93 97 56 245 22 74 20 31 ## Sample-360 14296 316 179 1321 103 61 87 64 38 100 79 2301 73 60 202 27 68 21 46 24 59 82 46 19 35 37 59 13 54 17 22 ## Sample-361 8145 992 1480 4548 391 188 102 38 312 459 97 1283 315 179 666 36 19 366 41 19 104 248 225 91 92 108 100 15 25 73 84 ## Sample-362 9751 356 913 1361 126 89 146 49 63 408 82 1458 185 107 583 32 72 38 16 18 87 211 105 36 13 45 115 11 93 44 58 ## Sample-363 9642 575 137 474 84 48 62 288 40 61 61 1823 34 33 113 42 38 15 23 25 26 39 32 42 14 17 59 12 8 15 18 ## Sample-364 2784 3189 572 1507 335 104 486 3684 127 132 171 358 133 101 236 154 698 37 125 99 45 51 64 110 24 36 111 17 10 53 35 ## Sample-365 42 892 105 3892 303 39 75 33 59 97 86 38 56 72 1364 20 23 74 17 20 68 39 72 89 15 72 294 10 43 14 15 ## Sample-366 13490 930 469 275 94 52 111 111 37 91 60 1990 92 57 61 41 79 36 22 46 43 75 48 26 14 45 49 55 34 25 47 ## Sample-367 213 314 35 519 42 28 94 15 16 26 42 83 20 20 156 20 76 9 13 16 15 13 15 8 2 17 36 7 3 7 7 ## Sample-368 7606 431 43 111 35 40 149 110 9 45 35 1382 22 16 27 17 76 9 14 17 15 18 26 9 2 11 10 9 4 8 9 ## Sample-369 3757 281 346 4656 114 47 65 55 50 219 50 465 119 74 178 22 36 83 27 22 110 255 97 68 42 38 267 13 20 19 37 ## Sample-370 23 96 123 2558 92 13 22 14 31 46 49 6 23 45 55 28 16 14 15 14 20 18 21 8 18 14 44 7 5 7 9 ## Sample-371 3886 728 518 2000 129 42 38 21 84 63 85 586 91 72 363 17 20 278 13 20 51 27 103 25 30 25 40 54 8 23 12 ## Sample-372 108 121 63 958 59 12 23 13 18 63 75 9 27 30 269 13 18 14 11 14 17 26 19 10 6 11 59 8 5 16 15 ## Sample-373 1001 769 129 1232 123 79 68 26 68 93 72 171 187 54 458 16 63 14 29 24 54 39 65 23 85 24 58 8 98 29 36 ## Sample-374 24 101 1689 5043 486 78 23 31 424 83 36 90 105 89 76 23 18 63 12 16 18 73 26 85 5 18 113 15 27 56 78 ## Sample-375 13384 1517 323 1060 50 61 154 25 39 148 124 1572 589 46 226 22 62 14 25 31 140 61 69 48 25 29 56 25 21 13 28 ## Sample-376 579 3374 600 49 476 946 360 431 329 308 1177 92 241 597 14 73 961 63 265 160 85 320 124 199 143 121 18 25 25 307 177 ## Sample-377 47 5703 559 2810 129 153 840 127 102 135 379 41 106 95 536 84 1408 51 80 50 67 65 100 69 42 33 198 13 69 26 39 ## Sample-378 16 2893 801 2351 85 354 413 329 178 349 148 16 116 63 1022 125 297 39 111 402 73 56 148 69 98 45 57 9 74 30 14 ## Sample-379 48 1845 1826 2638 116 165 172 181 59 1028 282 42 127 94 662 19 26 42 43 23 104 826 270 26 37 92 330 12 88 33 30 ## Sample-380 1601 1542 591 6009 64 242 88 25 40 202 289 278 104 74 1051 17 39 13 25 16 67 105 92 38 4 41 215 18 13 31 18 ## Sample-381 24 379 514 4941 138 77 34 18 73 118 408 28 169 136 174 47 28 50 12 17 62 184 57 96 7 14 99 10 9 30 18 ## Sample-382 12153 598 628 700 150 97 71 98 67 196 95 2303 124 101 175 111 22 85 39 21 48 206 56 81 34 30 63 49 60 17 29 ## Sample-383 24 877 1077 4935 149 103 113 35 69 564 98 36 162 88 212 37 20 55 18 29 79 406 263 38 17 165 144 19 42 37 123 ## Sample-384 327 590 150 6035 103 51 33 90 191 152 80 183 84 52 338 18 17 17 18 17 34 31 102 41 14 20 165 10 11 46 14 ## Sample-385 12153 886 559 135 71 96 113 465 31 76 69 1835 69 45 61 31 41 30 29 23 50 56 46 27 28 27 37 14 13 11 32 ## Sample-386 24 606 415 135 1647 189 226 324 1772 195 661 8 119 273 328 67 71 893 116 43 58 108 95 649 151 51 36 61 309 217 46 ## Sample-387 52 1729 24 993 131 1919 944 1136 54 295 544 101 27 105 1858 58 31 15 102 79 17 26 48 17 38 12 800 17 5 7 8 ## Sample-388 15 972 2044 62 353 346 357 47 79 623 543 7 66 206 607 414 116 62 52 28 103 102 109 231 198 57 833 33 279 45 20 ## Sample-389 112 352 941 250 1279 398 374 1689 1051 571 471 14 129 516 207 97 18 137 259 26 121 186 181 127 425 132 29 113 28 314 37 ## Sample-390 43 2185 708 1882 175 267 347 117 73 280 303 17 137 103 836 85 683 67 44 324 122 136 99 170 38 65 120 13 203 36 89 ## Sample-391 50 565 784 1334 631 466 218 165 607 334 321 16 166 299 397 40 19 100 66 43 166 144 196 68 137 481 80 116 212 56 47 ## Sample-392 118 86 1063 54 2333 235 28 35 1266 1001 298 24 284 715 29 102 19 97 24 20 222 92 597 66 7 91 17 854 388 317 63 ## Sample-393 48 3281 457 97 1225 159 534 1953 365 149 956 27 192 384 150 480 131 89 266 76 36 44 66 160 85 96 14 71 219 144 29 ## Sample-394 12 56 74 36 1879 1776 307 412 1653 108 905 5 306 458 33 672 55 271 666 37 53 35 158 41 769 113 9 46 34 327 55 ## Sample-395 16 706 1207 602 934 416 316 372 1121 1121 522 7 500 581 114 25 139 204 82 127 651 117 469 81 110 62 82 117 48 296 112 ## Sample-396 11 41 624 1339 1150 32 73 62 274 231 233 7 122 330 323 125 18 689 215 17 49 114 349 32 192 51 306 68 367 59 44 ## Sample-397 21 3085 364 170 337 592 339 394 392 134 433 10 76 249 129 77 327 365 122 644 78 147 111 55 14 139 19 35 56 185 29 ## Sample-398 74 1661 851 1281 411 70 475 348 241 344 363 93 679 207 197 65 363 84 176 628 166 114 189 84 33 162 133 29 157 136 64 ## Sample-399 9669 534 1947 1478 419 671 108 106 92 498 494 1320 57 270 418 31 22 28 91 53 40 23 97 91 34 14 86 92 25 12 11 ## Sample-400 31 464 468 1276 837 1208 497 784 932 229 516 13 115 264 329 399 18 154 183 50 126 31 137 297 191 158 106 15 264 644 30 ## Sample-401 27 3293 1099 442 523 582 733 2263 222 234 141 10 173 246 784 154 37 229 237 325 201 145 91 134 198 110 45 16 94 89 47 ## Sample-402 8700 453 1318 2259 728 497 191 198 487 466 273 1235 174 320 268 52 71 299 105 89 104 189 91 95 133 351 58 17 82 109 39 ## Sample-403 26 890 899 5053 787 310 422 292 314 448 321 26 240 244 460 69 198 575 164 55 201 85 239 185 157 530 607 25 238 113 133 ## Sample-404 2100 1093 1339 1119 1183 496 302 135 490 914 423 377 298 369 290 257 469 358 145 41 231 155 224 115 196 284 325 289 262 139 274 ## Sample-405 3343 2089 436 819 405 188 433 110 349 349 394 496 284 282 526 63 40 148 40 87 125 341 101 71 16 85 65 127 58 148 74 ## Sample-406 22 5240 640 1113 262 406 671 128 338 287 284 10 196 111 526 44 155 440 78 98 85 262 80 223 88 114 171 82 62 68 45 ## Sample-407 31 892 1801 3427 184 1068 189 452 85 186 193 28 61 65 180 85 29 28 121 31 60 33 53 202 91 28 440 23 125 14 18 ## Sample-408 23 2869 764 811 459 396 713 645 184 899 322 17 138 307 303 224 1036 131 264 264 159 102 211 21 247 207 120 28 459 228 41 ## Sample-409 10667 309 229 2925 440 78 50 32 165 989 200 1416 275 273 318 50 20 96 29 19 423 126 248 17 7 254 54 14 49 51 51 ## Sample-410 32 1773 545 477 1537 1301 425 1309 1641 431 509 11 141 709 521 346 103 437 284 89 90 135 177 72 312 138 136 51 164 370 30 ## Sample-411 14 3004 88 188 578 823 1105 1500 515 121 793 5 78 313 173 131 1228 390 157 145 34 108 45 28 355 68 17 24 58 61 43 ## Sample-412 6718 165 404 78 62 72 68 49 35 80 46 1400 123 46 58 27 51 20 43 69 39 32 37 28 26 27 23 13 21 19 48 ## Sample-413 26 4701 686 2109 516 777 532 177 150 737 593 24 590 226 1064 62 154 130 96 69 111 133 128 26 188 83 149 29 63 168 55 ## Sample-414 124 986 590 296 114 145 230 56 28 93 98 20 132 73 98 25 25 30 113 222 74 35 39 43 26 29 165 22 65 22 21 ## Sample-415 8563 649 393 545 207 158 189 60 54 240 81 1699 386 99 251 24 96 65 46 110 245 79 124 42 23 91 34 15 39 20 130 ## Sample-416 559 454 403 676 364 837 1259 670 138 278 423 121 241 254 164 39 133 75 348 879 201 132 251 61 248 169 46 50 64 91 105 ## Sample-417 23 117 1112 728 93 186 48 41 25 142 54 9 347 73 196 45 69 42 31 28 69 59 54 38 15 41 45 20 18 31 303 ## Sample-418 29 141 805 1501 146 81 59 38 35 105 60 12 47 91 138 21 26 162 18 25 197 100 90 19 3 67 430 15 15 25 22 ## Sample-419 777 726 832 227 77 432 272 83 38 215 137 432 142 89 124 49 580 61 104 89 240 41 70 176 32 50 34 24 23 23 42 ## Sample-420 62 1298 86 670 217 899 524 618 69 109 205 20 53 57 366 65 603 122 97 490 24 49 35 69 11 22 132 11 19 17 15 ## Sample-421 15 627 837 1700 90 153 189 75 107 185 73 9 338 55 366 32 271 58 53 211 66 122 121 77 40 45 69 20 27 32 192 ## Sample-422 8822 151 805 1048 101 44 44 31 27 281 49 1466 156 97 51 23 26 19 15 40 141 109 74 21 16 41 76 12 10 24 29 ## Sample-423 82 340 726 845 141 488 122 66 90 239 93 12 131 141 541 23 392 129 94 43 262 97 101 36 79 52 170 22 96 35 54 ## Sample-424 138 1810 445 239 170 206 868 697 60 131 145 83 181 49 216 21 76 88 131 217 98 35 52 79 65 38 31 17 44 23 93 ## Sample-425 24 1352 375 1258 209 889 572 832 86 401 241 13 171 94 721 109 1630 78 190 223 222 56 152 56 38 54 98 24 115 24 197 ## Sample-426 5772 1130 248 152 106 167 259 189 28 138 96 751 422 56 50 31 315 39 80 104 45 71 48 97 35 35 36 12 32 18 55 ## Sample-427 8186 122 470 142 41 72 51 32 21 143 27 1074 56 30 72 15 106 24 12 30 48 32 41 28 7 21 42 7 9 8 52 ## Sample-428 33 1535 1641 3034 452 380 578 91 225 685 197 17 625 168 212 54 237 403 50 609 320 735 260 59 120 159 93 51 121 91 775 ## Sample-429 11 2694 614 1443 283 1208 1183 624 84 209 284 5 242 97 108 19 30 53 111 33 473 82 242 75 77 50 165 21 21 38 48 ## Sample-430 23 915 525 1166 144 108 305 70 35 251 129 11 367 64 237 55 212 45 67 559 174 103 118 50 65 42 151 13 16 16 26 ## Sample-431 27 5591 279 327 529 536 2372 691 218 271 538 13 879 375 392 525 463 163 128 154 110 224 215 33 55 62 49 13 38 42 52 ## Sample-432 243 215 1916 2255 86 421 98 45 139 256 75 17 294 74 206 58 105 69 32 163 137 101 86 72 27 40 64 14 27 22 53 ## Sample-433 49 334 3495 4614 515 806 66 107 398 448 145 236 452 206 137 41 26 597 48 109 180 401 180 668 6 151 548 16 131 105 117 ## Sample-434 9305 831 1015 762 183 164 229 38 78 280 155 1522 195 102 228 14 37 47 23 38 228 232 145 26 28 110 61 12 16 31 38 ## Sample-435 4327 455 1258 1412 129 142 138 36 53 402 77 837 269 82 61 51 64 63 21 26 122 80 108 110 16 41 186 13 23 33 215 ## Sample-436 7463 3718 2034 814 475 1046 750 2156 159 235 287 1127 1028 291 374 52 579 61 209 360 90 101 202 105 110 65 75 14 32 74 82 ## Sample-437 267 880 688 235 130 265 539 188 73 194 151 50 246 93 316 37 495 98 104 121 99 59 57 45 57 24 29 12 21 48 141 ## Sample-438 3397 1340 1497 64 448 327 581 827 144 250 257 678 301 194 32 150 438 90 307 409 205 121 102 52 100 59 24 21 27 37 97 ## Sample-439 74 977 572 68 111 226 489 104 37 94 129 6 144 38 255 52 114 46 47 275 38 59 40 44 11 32 236 12 31 30 37 ## Sample-440 2009 853 950 308 204 369 279 520 64 210 123 448 287 106 237 43 674 69 65 173 113 66 72 67 43 104 30 30 33 40 173 ## Sample-441 66 2652 508 882 374 1583 394 1516 124 316 330 85 108 120 428 30 37 114 176 69 143 112 68 43 120 38 62 16 53 49 28 ## Sample-442 23 1811 1228 2775 172 476 388 73 91 488 217 12 606 123 346 39 194 99 51 228 269 285 150 172 35 67 121 28 48 39 237 ## Sample-443 51 1446 667 2268 286 484 338 461 96 221 195 15 1215 125 250 95 451 78 80 124 236 165 98 55 136 47 81 18 72 47 72 ## Sample-444 26 1724 615 392 111 345 671 522 28 272 205 6 139 72 240 35 263 30 90 629 69 72 86 127 48 47 29 10 74 22 26 ## Sample-445 15 1156 500 2210 80 103 748 60 30 125 167 9 48 38 109 26 25 96 61 31 66 45 31 91 39 18 104 14 12 14 18 ## Sample-446 13 1356 748 539 280 149 472 268 47 193 163 5 93 84 174 50 23 90 313 66 31 48 146 40 36 27 68 10 137 59 19 ## Sample-447 8910 855 529 204 138 146 357 316 65 157 90 1326 164 66 45 27 139 24 59 194 78 53 74 90 29 56 23 11 45 25 38 ## Sample-448 14961 540 1725 1989 152 189 305 152 63 189 117 1839 225 112 404 38 364 164 38 94 239 505 160 107 9 70 87 20 22 37 232 ## Sample-449 5193 1147 1745 574 132 305 518 113 43 174 195 734 164 85 223 40 413 65 64 511 108 68 80 92 20 32 25 19 16 41 48 ## Sample-450 69 2831 304 333 317 438 590 759 73 127 232 15 100 88 641 191 480 137 202 248 45 74 48 64 82 39 130 21 65 61 32 ## Sample-451 58 440 1886 2039 107 232 74 131 61 189 82 13 286 75 262 41 69 35 30 33 329 76 92 32 6 49 60 10 111 30 64 ## Sample-452 14 376 795 3712 149 663 75 46 73 766 142 10 81 175 250 33 26 46 42 23 355 37 111 60 20 68 426 14 32 25 25 ## Sample-453 79 960 575 315 352 533 373 980 125 164 169 14 103 104 446 696 655 92 105 372 122 99 69 143 56 50 73 28 54 37 33 ## Sample-454 228 2501 1093 3666 345 205 290 50 189 592 223 36 2008 179 615 50 423 134 26 582 318 306 348 60 72 122 368 33 71 69 100 ## Sample-455 43 1423 931 1053 489 554 547 565 587 505 413 17 166 218 618 97 664 55 122 61 65 161 183 117 110 111 135 28 187 69 46 ## Sample-456 19 430 957 1664 144 192 112 114 43 244 68 11 48 87 84 55 26 56 30 24 106 45 122 52 4 48 170 29 84 49 25 ## Sample-457 38 51 1583 1178 117 214 68 40 62 267 45 10 196 100 68 79 19 64 74 21 120 89 75 57 39 67 51 25 97 52 57 ## Sample-458 54 278 126 29 136 110 66 30 13 555 163 7 81 99 165 25 28 36 29 16 191 44 158 49 6 16 52 11 8 27 59 ## Sample-459 235 593 473 359 151 295 226 812 53 179 118 10 320 60 237 51 433 26 64 71 181 50 42 33 12 28 39 12 37 65 61 ## Sample-460 125 670 538 1199 135 116 263 57 51 226 116 9 422 89 168 38 114 155 31 73 133 87 100 45 22 71 63 26 23 29 132 ## Sample-461 9843 2651 2716 2290 240 380 356 438 177 565 214 1107 512 176 325 45 165 149 39 400 215 295 355 95 151 110 128 25 61 85 666 ## Sample-462 8243 371 352 56 62 91 72 256 21 102 41 1019 119 36 21 27 47 18 29 41 26 31 33 21 14 22 15 26 46 15 101 ## Sample-463 94 677 182 285 80 233 936 252 21 125 231 67 114 39 191 20 296 35 207 488 30 37 35 21 51 18 84 12 25 14 23 ## Sample-464 184 1000 324 893 96 95 207 341 64 136 91 10 286 46 356 36 49 26 34 192 42 41 52 26 21 34 47 9 23 21 64 ## Sample-465 24 910 848 2202 98 372 178 94 35 509 112 12 840 89 455 51 537 52 66 106 152 204 138 186 64 45 61 15 32 43 199 ## Sample-466 13 585 1465 263 169 707 326 121 66 88 112 5 80 63 438 85 119 33 83 268 74 38 42 66 70 21 46 16 20 25 41 ## Sample-467 10466 135 439 780 112 273 44 53 55 441 51 1506 182 73 91 20 24 45 22 19 147 45 188 23 21 25 61 11 36 19 57 ## Sample-468 8235 447 1101 1154 113 65 125 146 32 425 148 1192 62 133 275 28 166 64 59 43 213 69 94 89 54 43 224 14 76 38 17 ## Sample-469 21 1414 1578 4485 297 622 574 142 214 356 229 23 147 154 813 123 110 142 134 170 330 140 138 248 126 54 394 70 45 76 75 ## Sample-470 26 23 22 2091 204 49 38 15 52 1301 144 18 49 486 72 29 16 42 12 15 820 22 101 8 2 22 427 32 6 15 13 ## Sample-471 24 247 277 1796 677 1374 97 286 616 1322 199 22 81 337 236 43 20 130 157 31 124 104 543 16 261 164 167 14 63 147 20 ## Sample-472 76 573 1332 2898 354 406 81 119 177 215 115 21 59 81 722 187 20 167 39 49 258 57 46 160 52 27 112 11 80 38 24 ## Sample-473 1443 1345 680 1075 131 223 479 92 164 276 129 702 122 99 857 51 1037 77 51 471 196 172 111 69 53 49 140 14 64 57 175 ## Sample-474 8911 2298 523 1176 173 267 317 206 145 427 130 1050 104 99 454 22 189 154 45 154 102 145 97 86 25 56 147 14 38 18 75 ## Sample-475 57 1234 1489 2230 188 237 126 251 79 664 141 33 249 140 483 45 37 41 33 129 165 167 233 39 53 62 251 11 55 41 40 ## Sample-476 262 474 284 1426 121 57 70 348 41 264 62 133 62 104 171 15 17 23 31 17 150 25 96 13 19 41 97 9 11 32 33 ## Sample-477 3179 1733 728 3444 141 164 284 45 44 337 100 501 183 88 560 21 112 49 29 200 316 220 159 124 51 51 647 21 10 36 32 ## Sample-478 106 2741 598 715 322 1049 402 605 84 632 472 135 163 290 1017 61 43 106 63 80 319 249 445 78 197 197 97 20 109 41 43 ## Sample-479 9306 990 514 84 142 112 263 301 81 65 114 1430 100 46 48 16 269 12 59 429 33 33 41 28 7 19 15 10 7 27 27 ## Sample-480 88 3620 370 1499 220 1042 1232 503 122 218 397 11 184 104 527 42 404 209 94 341 89 75 62 66 52 69 280 15 84 95 101 ## Sample-481 6156 691 1399 750 261 370 535 228 191 380 150 846 134 138 307 55 600 76 75 218 154 126 214 243 44 108 179 14 106 27 42 ## Sample-482 19 622 2006 1298 155 293 156 328 102 526 83 9 313 83 589 95 452 216 75 302 297 200 108 71 83 55 93 20 34 55 387 ## Sample-483 21 2101 897 1357 123 299 732 66 123 169 189 9 840 72 313 39 712 114 72 223 72 98 84 42 100 48 45 31 34 67 350 ## Sample-484 11 2387 45 589 110 83 847 621 48 206 282 5 52 81 141 34 203 31 169 61 40 34 52 32 176 40 496 9 10 21 10 ## Sample-485 114 2349 1276 799 195 125 337 1021 69 333 186 38 148 130 516 123 566 139 111 169 105 172 185 130 108 64 260 25 106 42 53 ## Sample-486 8782 886 891 1278 155 142 207 182 103 236 131 1168 81 119 250 39 36 208 30 60 115 115 103 56 24 49 79 12 22 29 51 ## Sample-487 1526 1627 755 535 471 664 485 276 202 372 442 184 280 271 393 177 1482 248 174 929 113 63 83 93 86 47 183 14 56 133 157 ## Sample-488 2925 1510 668 1118 351 659 306 999 212 359 222 579 190 216 673 77 22 36 154 97 155 91 112 56 218 65 144 10 76 62 35 ## Sample-489 11023 660 272 762 104 62 168 54 29 390 184 1401 378 216 448 38 18 65 39 23 294 219 114 22 43 53 184 11 140 37 125 ## Sample-490 226 536 1380 971 148 138 126 51 192 217 121 93 170 128 216 76 100 38 53 135 103 137 130 50 99 65 93 23 91 70 47 ## Sample-491 7187 1196 476 3150 157 235 89 656 40 2330 773 1075 300 413 624 36 18 50 41 17 247 31 671 14 8 51 316 11 11 46 17 ## Sample-492 38 377 641 3932 161 90 36 18 42 188 137 27 119 316 412 78 17 67 14 19 367 269 73 23 2 29 772 12 18 64 40 ## Sample-493 13 2566 223 6488 410 58 102 122 72 460 210 19 146 47 662 23 16 49 74 29 36 36 149 35 131 25 355 10 73 91 22 ## Sample-494 15 2862 1755 3847 157 213 552 365 149 257 175 9 870 100 144 17 339 82 84 277 114 293 106 118 185 85 78 26 68 59 125 ## Sample-495 239 1276 914 348 88 226 259 40 44 100 96 23 170 52 384 12 30 68 44 35 109 31 52 73 47 44 177 10 43 18 99 ## Sample-496 22 789 2386 2111 205 396 162 41 77 196 192 18 260 127 231 43 271 186 39 69 300 130 120 99 56 57 106 11 147 36 41 ## Sample-497 13 208 256 2304 198 63 35 30 198 821 198 15 278 170 149 87 19 99 14 21 169 133 335 14 2 73 243 20 121 87 39 ## Sample-498 15 639 1602 929 94 418 182 248 59 144 93 11 320 60 492 144 565 215 27 420 77 91 62 43 34 34 130 151 34 28 405 ## Sample-499 16 983 404 1470 156 827 169 111 106 139 130 10 84 97 651 154 807 50 64 76 54 68 69 54 131 34 175 180 26 49 24 ## Sample-500 28 415 815 4342 254 177 183 655 53 916 183 26 178 105 497 24 39 43 46 38 134 180 95 25 21 22 474 11 47 72 45 ## Sample-501 13 210 2332 3303 164 71 58 37 77 225 116 12 153 111 228 71 18 122 24 18 225 116 72 125 12 17 137 30 20 72 81 ## Sample-502 28 936 943 4027 144 222 251 231 58 744 156 24 301 154 693 66 146 165 56 100 231 179 265 36 90 67 426 12 91 43 174 ## Sample-503 5328 1595 403 862 94 159 450 156 85 158 143 1071 304 71 454 33 940 21 177 700 52 104 84 36 17 34 62 12 110 25 71 ## Sample-504 19 905 538 776 72 143 269 117 30 88 91 25 145 42 476 29 67 105 52 103 46 49 43 70 66 28 93 11 31 16 43 ## Sample-505 843 4308 411 209 87 145 1234 97 79 92 201 110 131 39 66 12 203 22 127 247 46 46 40 40 21 21 15 9 21 11 58 ## Sample-506 17 1305 1381 3183 136 81 80 51 33 1218 369 18 91 137 634 38 21 109 26 20 71 68 420 43 37 17 737 15 20 36 22 ## Sample-507 33 4068 390 1105 226 148 609 537 42 122 155 11 144 74 478 64 52 72 85 430 215 50 46 40 56 52 139 25 52 27 77 ## Sample-508 11303 959 359 237 98 95 243 161 51 160 75 1558 187 61 60 17 85 17 32 91 76 64 74 25 23 23 24 10 19 13 52 ## Sample-509 22 1784 235 581 577 2359 468 524 575 710 227 5 125 287 87 68 20 122 284 151 43 65 128 38 99 32 14 13 10 34 31 ## Sample-510 1644 4626 396 76 204 107 913 1776 106 113 224 231 265 63 82 49 1623 28 170 830 41 33 49 53 145 23 86 13 13 23 25 ## Sample-511 31 1180 1272 2690 123 221 168 35 35 307 111 28 367 122 275 19 54 36 50 28 210 47 113 50 39 26 358 10 29 62 239 ## Sample-512 16 1601 1525 4295 175 239 449 130 47 476 201 16 105 121 718 43 53 172 95 22 297 423 191 287 146 87 188 16 258 42 102 ## Sample-513 43 1202 1091 995 148 416 322 55 84 259 155 21 95 101 438 38 186 65 47 57 145 113 132 107 27 55 123 55 16 30 41 ## Sample-514 29 2028 709 873 90 83 574 28 39 435 179 8 56 81 505 15 188 27 43 43 616 42 57 66 32 46 93 9 32 12 20 ## Sample-515 3819 458 1095 555 124 260 109 51 42 156 49 658 117 95 177 14 146 109 51 40 100 82 64 40 46 104 46 25 26 19 28 ## Sample-516 11797 570 736 51 68 61 87 325 42 76 51 1626 42 38 34 12 37 8 29 17 31 32 43 29 19 15 14 15 6 12 20 ## Sample-517 31 1010 1755 3118 141 348 236 61 71 258 115 26 116 105 567 17 19 204 110 83 120 153 145 217 154 55 106 30 184 57 86 ## Sample-518 173 4088 369 1085 107 251 807 267 41 271 228 19 227 118 576 16 242 37 189 149 113 41 72 40 293 29 63 14 15 25 22 ## Sample-519 9028 978 481 168 67 111 193 103 13 128 98 1741 216 41 223 14 138 17 41 213 54 32 26 27 12 28 33 16 9 13 32 ## Sample-520 19 3395 261 364 149 159 909 498 17 78 126 6 42 24 534 15 24 19 86 177 30 36 22 61 19 14 64 9 14 7 13 ## Sample-521 955 3357 590 202 161 147 1275 182 23 225 226 223 523 74 170 13 238 31 85 226 56 64 86 46 98 58 35 30 11 27 58 ## Sample-522 10232 3247 970 734 220 223 1023 101 81 202 226 1393 193 94 230 13 436 119 82 608 190 217 147 51 97 82 109 23 129 26 55 ## Sample-523 42 2485 795 1707 182 333 392 372 49 305 177 8 290 100 322 15 145 37 119 279 100 114 67 70 43 57 61 13 11 16 116 ## Sample-524 3428 5881 337 345 480 811 1330 1179 37 283 316 570 47 131 147 14 33 92 291 215 73 48 82 255 64 35 153 13 91 26 24 ## Sample-525 185 2176 1454 2704 438 146 1658 156 308 611 290 15 395 185 447 13 93 115 237 319 122 365 246 105 173 93 156 14 32 68 134 ## Sample-526 47 5440 621 2686 309 441 537 117 19 1564 519 43 282 617 519 13 607 84 132 404 835 154 737 86 113 28 184 18 43 79 30 ## Sample-527 48 2928 396 2531 448 469 808 246 124 708 315 18 226 463 1136 15 73 79 217 58 515 169 317 58 315 51 166 18 334 61 178 ## Sample-528 7950 4315 446 239 229 235 1063 332 38 174 250 1160 286 57 220 14 2630 30 134 375 42 79 93 77 22 41 61 62 24 23 91 ## Sample-529 6384 2191 2585 397 222 182 281 146 227 165 206 978 145 166 128 15 41 232 83 45 127 83 109 72 136 76 40 80 172 80 42 ## Sample-530 18 7520 157 411 209 562 2299 986 27 98 559 5 119 102 362 21 438 54 546 356 47 20 35 22 378 24 48 10 58 13 21 ## Sample-531 1397 5080 388 925 151 346 1105 544 30 528 227 219 124 82 182 12 123 30 88 124 60 140 64 390 100 30 109 9 46 21 188 ## Sample-532 34 1338 621 2601 289 396 214 78 141 231 190 14 97 105 843 14 67 41 104 18 163 149 77 50 110 74 132 19 26 32 43 ## Sample-533 30 1121 607 4920 391 531 91 72 93 876 155 22 120 116 226 15 20 295 100 19 237 579 72 20 82 188 614 22 20 55 29 ## Sample-534 1089 5549 686 235 393 274 1175 2262 116 118 305 157 72 60 214 14 44 75 202 330 56 65 83 33 144 31 39 10 11 17 15 ## Sample-535 20 1890 732 2301 139 280 404 981 56 110 155 9 85 92 914 14 184 30 75 448 58 38 63 299 81 47 134 37 44 28 30 ## Sample-536 13 2106 135 677 118 181 831 1017 124 146 189 7 49 52 258 14 918 40 116 404 23 33 39 21 72 19 58 31 40 12 13 ## Sample-537 21 1260 2151 2012 106 278 476 50 64 166 99 7 165 86 114 13 70 64 69 98 105 61 118 106 122 40 312 58 56 65 90 ## Sample-538 1020 412 2513 527 346 407 91 90 209 270 98 173 92 130 337 17 85 109 29 113 93 57 124 75 55 64 44 58 31 28 23 ## Sample-539 19 1058 499 1814 149 134 132 651 118 248 116 7 180 167 699 14 173 124 68 40 222 71 94 63 142 66 227 10 60 39 245 ## Sample-540 172 1574 269 739 105 376 473 798 28 112 132 13 179 71 185 15 167 20 99 200 93 42 47 33 156 26 145 11 50 40 21 ## Sample-541 11308 845 247 137 62 115 109 79 28 77 61 1521 49 40 109 12 337 12 18 26 41 30 34 19 10 18 28 8 11 10 29 ## Sample-542 2369 3832 575 1001 151 412 525 260 109 240 165 389 153 63 240 13 328 70 43 129 350 173 90 57 18 65 132 17 19 30 85 ## Sample-543 50 957 458 3425 172 198 326 90 79 811 83 13 53 313 47 12 20 29 62 37 282 34 278 18 89 50 142 11 108 77 18 ## Sample-544 2930 3161 1011 2150 173 348 444 148 124 291 107 567 73 109 534 14 108 152 46 84 106 107 109 189 49 33 83 10 37 50 41 ## Sample-545 6344 2157 613 698 148 229 521 691 78 272 124 863 107 95 201 13 155 259 55 196 122 169 208 103 88 47 53 14 25 53 65 ## Sample-546 1510 4772 652 770 185 85 603 82 104 410 203 214 1314 82 334 13 97 139 57 217 168 132 130 150 136 63 133 11 18 32 112 ## Sample-547 24 1297 1616 3590 308 1033 358 109 156 214 137 11 238 153 577 15 96 88 61 498 256 62 147 52 69 95 350 58 121 59 34 ## Sample-548 70 474 1562 1625 404 723 372 1937 347 550 178 36 98 261 472 14 213 558 158 32 218 79 192 74 158 72 89 15 80 74 61 ## Sample-549 10642 3283 1339 1296 159 203 788 320 47 332 177 1751 510 98 186 14 355 47 98 199 224 114 257 89 105 61 74 20 67 42 36 ## Sample-550 40 2785 871 1202 245 185 643 806 356 452 159 12 83 153 1013 17 1400 44 83 547 150 463 148 130 161 58 186 17 21 30 34 ## Sample-551 960 2264 412 345 208 116 1190 1026 65 154 274 380 127 55 87 13 175 40 117 411 50 89 67 153 59 54 28 11 24 27 49 ## Sample-552 15 4101 1536 2579 199 591 337 268 167 148 105 9 86 111 367 14 225 19 71 162 183 72 63 292 69 25 121 10 74 59 27 ## Sample-553 16 3695 1655 3009 409 122 778 987 79 373 236 17 69 155 747 15 443 92 112 293 102 83 142 233 192 54 110 16 36 71 20 ## Sample-554 35 1581 655 2998 372 101 68 187 114 605 196 25 59 158 502 14 20 213 61 29 28 128 234 66 7 34 1202 17 14 58 34 ## Sample-555 12 967 488 1421 386 98 182 84 50 274 171 20 191 53 206 13 29 66 125 23 24 152 37 46 150 12 32 9 8 12 13 ## Sample-556 15 1345 1436 1816 219 204 278 121 111 511 183 8 378 149 444 13 239 85 110 166 177 264 289 55 228 223 374 12 139 51 397 ## Sample-557 422 4238 604 888 105 407 522 264 45 490 226 59 114 69 202 13 92 31 49 45 148 45 111 78 42 31 23 13 27 25 97 ## Sample-558 50 3227 468 2775 379 267 135 97 48 527 227 20 246 201 734 15 19 30 144 22 282 24 318 16 9 36 752 11 70 20 16 ## Sample-559 6350 2524 1270 752 218 126 546 118 128 333 238 894 287 103 395 13 289 54 40 111 216 157 128 46 59 44 50 160 12 45 60 ## Sample-560 23 3760 933 3164 198 219 1250 77 91 492 205 13 48 90 904 12 18 105 63 144 76 83 101 527 74 67 304 86 35 36 39 ## Sample-561 32 2825 1259 3454 256 440 731 99 128 348 175 22 175 104 764 15 77 216 123 434 128 231 173 133 191 84 226 44 42 51 50 ## Sample-562 33 1129 254 2810 319 51 205 291 212 695 133 12 87 185 448 12 23 51 60 120 261 43 198 50 39 79 294 13 22 56 28 ## Sample-563 11688 3132 645 798 121 90 469 967 35 191 121 1747 193 75 442 13 50 69 52 67 141 192 136 91 16 34 119 11 41 38 318 ## Sample-564 51 1740 1425 778 215 796 207 149 146 175 150 9 110 161 746 21 110 33 236 26 165 34 50 85 403 21 56 24 63 33 23 ## Sample-565 5478 2409 1021 1263 142 194 575 149 80 207 131 1087 51 140 47 17 49 222 26 212 65 103 127 96 17 54 98 13 17 32 44 ## Sample-566 16 4344 648 2294 292 1093 858 496 149 309 443 11 302 190 442 15 207 71 132 168 87 77 147 30 70 64 232 23 147 95 61 ## Sample-567 6604 3977 1146 817 288 412 590 623 261 690 189 1060 239 177 402 13 53 90 99 55 187 64 177 59 90 43 102 15 16 66 31 ## Sample-568 6669 3889 440 295 219 728 1861 800 94 96 238 1007 86 71 439 16 705 42 113 324 42 57 45 41 22 42 45 19 60 18 44 ## Sample-569 27 1869 1338 3594 389 539 388 1044 344 635 110 15 588 187 242 16 77 157 93 551 316 283 217 87 103 92 115 24 67 50 93 ## Sample-570 3466 3786 483 348 545 549 979 487 320 204 440 610 436 187 261 18 2055 209 190 248 77 87 114 158 59 106 36 19 480 68 49 ## Sample-571 42 4010 581 1653 269 659 922 670 165 242 616 11 191 279 1171 32 391 109 479 271 98 147 122 119 395 75 110 22 137 42 48 ## Sample-572 95 558 1892 825 215 701 489 931 83 228 121 9 179 134 269 14 475 41 99 220 163 99 93 157 134 53 187 38 174 101 72 ## Sample-573 105 400 1394 1083 560 147 327 255 235 1447 141 10 150 193 444 17 162 284 145 124 367 90 394 97 269 50 600 102 194 54 101 ## Sample-574 32 3098 948 1400 424 795 1272 408 136 298 267 15 203 129 765 15 444 127 238 602 79 56 134 59 161 58 165 19 94 26 83 ## Sample-575 26 1975 1345 4689 305 86 191 120 89 840 142 17 102 266 217 12 19 116 114 83 282 442 136 117 11 51 343 19 98 66 27 ## Sample-576 40 1495 218 3941 363 43 123 86 48 686 223 21 389 234 734 14 20 144 141 19 279 118 88 61 100 58 566 11 20 58 567 ## Sample-577 4869 4347 549 417 186 330 982 167 55 131 169 716 126 53 548 15 1454 100 79 413 67 51 82 32 16 33 35 13 65 15 24 ## Sample-578 3351 5688 921 343 422 185 1338 236 87 335 316 639 238 97 455 13 144 86 62 356 104 47 135 90 39 59 80 21 36 20 51 ## Sample-579 6450 2798 489 192 147 288 1596 323 72 169 181 947 213 66 85 15 294 50 114 532 44 61 50 26 43 18 16 18 9 23 102 ## Sample-580 25 921 1799 3103 421 870 99 451 327 175 226 11 214 153 75 14 31 80 52 18 253 90 76 94 102 48 143 14 155 30 196 ## Sample-581 12 2024 654 39 266 463 434 157 74 109 179 5 43 63 130 12 578 254 142 404 111 34 115 58 29 51 69 16 21 16 17 ## Sample-582 11 435 826 373 893 710 689 51 322 719 292 5 101 507 223 19 20 376 93 22 412 126 171 23 7 314 144 64 1174 195 49 ## Sample-583 38 1478 536 149 411 27 167 157 22 307 491 22 424 112 433 14 18 76 214 17 63 78 245 15 124 44 27 10 12 35 28 ## Sample-584 12 883 2189 4540 135 15 96 25 102 590 75 11 157 86 69 13 17 67 22 24 265 88 161 43 11 58 79 17 12 32 62 ## Sample-585 55 3316 76 1031 544 395 285 188 43 944 417 20 152 229 722 13 17 86 291 17 151 190 61 16 150 67 159 11 9 27 18 ## Sample-586 7811 1057 2119 288 62 213 280 71 42 114 92 988 253 56 195 13 51 18 44 133 96 73 74 82 27 28 33 17 31 27 35 ## Sample-587 7190 3746 793 848 220 75 1338 1558 29 143 297 999 118 80 615 13 48 45 287 37 81 45 45 51 183 33 58 10 9 17 116 ## Sample-588 15 3549 296 2041 361 1099 661 923 67 227 174 9 102 83 282 12 78 53 88 139 114 85 98 114 27 105 70 12 56 19 34 ## Sample-589 49 3177 1567 1299 154 154 1266 472 65 373 292 15 119 86 336 15 432 181 603 446 88 60 164 449 436 54 88 19 78 19 27 ## Sample-590 24 706 1654 2737 279 333 197 81 121 380 168 14 281 121 389 14 24 73 33 37 368 194 133 191 34 32 183 13 71 33 399 ## Sample-591 129 2920 802 1677 131 377 395 820 49 270 183 15 317 65 282 13 705 416 89 174 61 76 129 131 62 37 207 12 32 17 58 ## Sample-592 8569 3956 318 123 145 134 1606 611 48 199 276 1242 145 75 169 12 18 39 118 174 62 58 76 49 68 27 15 9 29 17 227 ## Sample-593 37 2375 1294 387 111 157 679 66 45 273 225 7 282 100 494 13 279 87 56 459 223 105 125 166 36 41 188 26 70 34 169 ## Sample-594 34 1703 1631 2107 221 644 358 93 140 474 169 11 243 100 458 13 596 127 47 29 141 391 137 111 40 162 130 17 63 21 108 ## Sample-595 8543 5758 1053 1352 311 79 606 361 44 194 219 1133 186 128 258 14 43 29 118 73 254 43 71 64 147 62 106 9 10 40 25 ## Sample-596 1091 2425 891 2001 930 107 230 155 68 1344 275 137 79 423 345 16 24 161 89 28 490 95 225 31 36 78 207 30 10 225 19 ## Sample-597 52 1608 827 2720 103 531 268 42 107 185 126 17 424 58 198 14 40 89 58 22 413 45 70 39 7 58 97 19 59 27 508 ## Sample-598 7312 2296 1748 74 240 138 422 840 75 218 218 1056 345 92 34 14 379 128 149 321 90 72 127 57 40 47 17 19 25 23 57 ## Sample-599 9517 2802 781 537 414 544 819 605 122 184 368 1910 208 94 89 14 370 76 198 62 122 53 155 78 38 43 29 20 19 28 124 ## Sample-600 37 793 2092 3121 317 294 258 135 93 418 246 11 156 173 199 17 23 108 113 26 104 165 93 110 73 136 134 526 93 89 75 ## Sample-601 3375 1502 1279 404 148 368 656 118 90 120 201 554 400 66 138 13 109 41 220 305 104 55 39 61 117 40 30 27 21 41 321 ## Sample-602 17 275 948 631 159 310 206 22 92 532 96 5 318 228 330 12 17 192 30 67 384 148 120 117 323 159 61 20 344 53 77 ## Sample-603 12 93 2442 3081 630 1032 73 67 122 726 92 10 128 148 82 16 217 253 20 19 332 48 161 227 533 57 819 37 14 54 26 ## Sample-604 44 2511 944 1775 106 258 237 86 24 335 302 37 34 83 380 12 169 22 92 96 67 20 55 202 11 57 1043 14 13 23 14 ## Sample-605 43 3303 1544 76 272 810 501 1252 34 782 272 7 307 200 336 12 17 72 191 151 518 68 144 300 188 71 871 13 23 43 390 ## Sample-606 9367 2333 886 418 445 675 1063 1084 366 327 269 1355 150 129 579 13 313 141 97 160 260 80 101 78 49 121 59 13 153 56 42 ## Sample-607 12100 1068 843 440 93 69 192 90 33 160 77 1551 205 69 43 12 556 44 43 54 58 54 82 55 37 48 29 15 41 22 240 ## Sample-608 213 1201 2570 3408 507 231 1001 292 350 466 253 17 431 308 356 16 570 1265 206 632 339 243 215 131 176 446 119 27 186 106 169 ## Sample-609 48 7080 471 360 650 621 1695 1476 171 153 1161 12 396 322 156 16 211 42 414 198 54 67 234 45 76 62 30 16 42 87 141 ## Sample-610 12764 1803 1369 1463 211 177 294 1522 78 319 178 1746 258 141 348 20 79 52 211 79 145 95 115 119 78 40 53 14 25 48 51 ## Sample-611 12052 2955 2536 882 175 157 489 216 69 338 225 1453 366 171 722 24 167 35 117 114 246 88 160 221 25 69 143 21 110 36 85 ## Sample-612 11 2148 20 133 694 120 95 28 28 631 732 7 48 306 99 17 82 98 20 17 57 561 754 13 99 34 1239 10 11 47 13 ## Sample-613 442 6834 315 1320 241 477 1435 840 59 202 181 84 117 69 360 15 397 44 221 716 52 72 58 83 302 56 150 14 48 27 24 ## Sample-614 261 2659 1394 871 152 293 327 99 54 1039 328 11 244 132 297 14 21 239 94 83 409 197 161 55 44 91 153 19 27 67 60 ## Sample-615 526 2472 968 541 139 257 651 148 52 141 124 81 242 55 105 14 128 36 104 325 57 30 59 53 132 55 27 17 36 18 41 ## Sample-616 15 5807 527 1202 117 183 1186 59 122 301 255 10 87 81 555 17 365 25 112 419 28 76 62 90 69 12 292 25 22 10 32 ## Sample-617 41 3723 1118 1648 128 188 668 232 40 124 165 10 99 51 161 17 236 36 101 99 72 52 72 43 102 36 59 10 10 21 61 ## Sample-618 10906 660 1500 629 120 167 209 225 44 205 92 1610 299 53 302 12 73 62 82 93 100 74 65 150 59 37 97 59 52 17 63 ## Sample-619 13 2901 431 1277 127 143 806 575 60 309 313 13 110 79 181 14 38 108 72 178 247 47 81 114 19 46 94 373 17 67 74 ## Sample-620 21 1224 454 1262 118 30 455 74 41 150 137 9 421 53 137 13 143 50 132 517 45 26 141 26 215 47 111 10 18 19 45 ## Sample-621 65 2155 1304 1074 584 930 1351 272 243 548 273 8 217 203 275 14 197 213 158 269 581 141 159 177 148 62 82 36 140 103 44 ## Sample-622 41 4178 134 1773 241 208 1321 174 235 281 526 10 108 90 642 13 116 30 126 772 23 51 65 66 9 139 55 115 14 13 55 ## Sample-623 7326 3653 936 690 163 165 1258 847 57 204 298 1086 685 71 65 15 435 29 126 883 45 98 63 119 95 34 37 12 11 30 103 ## Sample-624 61 4141 1035 1545 756 222 545 1059 90 567 571 26 70 90 530 17 31 298 250 38 104 40 118 128 207 120 200 19 161 20 39 ## Sample-625 18 1245 594 1641 214 610 1200 1051 78 112 158 8 363 69 129 17 718 182 115 66 71 118 56 103 68 31 116 14 13 32 88 ## Sample-626 68 3091 2775 1209 149 320 524 301 112 300 304 9 241 76 171 15 412 67 277 246 62 50 77 156 162 34 120 177 15 42 50 ## Sample-627 84 5921 1149 1867 176 240 809 97 66 412 276 108 342 82 380 17 138 49 65 89 171 46 167 70 44 66 448 16 217 25 31 ## Sample-628 15 5719 699 1955 306 156 744 75 127 443 161 11 104 94 125 15 42 201 70 232 99 125 136 204 87 71 88 30 53 32 83 ## Sample-629 8210 2852 783 390 79 271 439 66 27 146 166 1134 241 42 259 13 128 53 43 168 35 41 65 49 19 25 43 10 28 14 18 ## Sample-630 426 2140 1039 609 115 64 465 50 40 109 115 46 427 63 185 13 242 82 27 286 64 50 148 58 11 35 51 10 12 30 80 ## Sample-631 11 2063 967 415 125 174 298 45 50 184 112 6 243 67 344 13 179 39 33 42 75 44 151 67 25 130 53 22 43 34 292 ## Sample-632 14 847 735 5440 120 119 44 14 22 144 188 14 29 88 94 14 17 28 12 15 63 169 40 28 2 33 395 11 47 47 11 ## Sample-633 24 1057 1271 4068 116 126 172 37 49 409 147 14 121 82 584 15 22 50 22 67 143 102 126 66 18 33 187 11 41 43 121 ## Sample-634 2432 4815 51 493 160 347 670 770 19 324 211 450 294 62 98 14 33 149 103 105 34 31 52 23 86 60 134 15 341 11 41 ## Sample-635 439 6224 532 1917 121 386 1281 125 42 116 370 74 83 61 291 15 221 18 159 606 51 50 69 33 9 51 61 11 12 21 81 ## Sample-636 24 866 1205 2155 166 344 595 93 107 210 161 11 403 74 391 16 225 389 168 147 134 124 73 81 270 28 140 17 13 35 61 ## Sample-637 16 495 470 3210 104 28 45 17 47 913 280 13 51 162 105 14 19 57 14 17 138 198 245 40 2 54 557 53 10 22 12 ## Sample-638 12 1656 506 2808 94 287 390 57 38 214 149 9 81 72 172 14 156 165 38 111 84 83 110 48 34 69 62 20 23 20 43 ## Sample-639 17 8181 2367 2675 451 550 3209 2051 149 387 616 15 407 178 199 15 21 177 501 600 128 155 231 304 551 70 170 25 119 67 41 ## Sample-640 17 7703 2017 1678 243 334 1382 769 290 390 513 14 218 132 307 15 186 390 170 828 132 140 130 72 68 67 284 30 28 39 79 ## Sample-641 107 8472 1286 2255 147 267 1709 345 61 196 288 28 413 75 316 17 377 51 163 648 92 53 175 52 44 41 122 21 12 19 35 ## Sample-642 1723 6838 1077 961 280 332 3759 282 219 290 621 290 338 74 61 15 795 36 211 544 61 102 107 144 103 52 32 18 21 24 441 ## Sample-643 58 5547 3140 2867 349 216 1228 912 105 918 273 21 194 178 380 17 97 139 207 465 211 339 108 388 243 125 70 19 113 64 92 ## Sample-644 11271 710 2187 873 76 131 98 32 48 250 103 1877 251 102 172 13 102 28 22 71 169 76 140 131 39 29 135 11 18 23 406 ## Sample-645 5682 2316 829 373 122 261 477 912 54 147 149 710 260 69 244 13 307 22 61 195 108 50 48 45 40 38 65 10 73 34 282 ## Sample-646 46 2906 90 1247 186 237 312 237 67 507 284 9 155 168 1205 13 143 22 104 318 200 112 142 16 47 80 56 14 11 30 13 ## Sample-647 2991 2567 772 165 142 201 427 82 56 124 176 386 169 74 152 14 311 41 109 634 78 50 46 37 51 42 27 10 23 23 42 ## Sample-648 39 2167 1285 2301 154 323 482 485 74 297 242 15 598 105 438 15 155 53 192 80 232 54 108 79 118 54 112 17 69 61 77 ## Sample-649 52 3702 1311 1783 118 96 471 162 52 291 269 30 523 100 237 15 278 142 84 190 65 111 93 81 92 75 49 15 21 51 78 ## Sample-650 17 243 1978 522 191 293 86 1328 51 616 60 10 300 82 198 13 19 118 56 35 230 273 120 184 25 60 136 11 28 54 436 ## Sample-651 188 1293 1113 558 135 185 143 95 64 473 103 13 607 107 257 16 148 55 39 66 119 60 104 72 39 86 185 36 52 51 455 ## Sample-652 318 3289 1195 2833 150 410 1413 66 62 378 294 22 145 109 250 17 350 73 102 163 135 108 113 131 124 39 111 53 113 45 131 ## Sample-653 7347 3604 1086 388 195 145 827 219 78 326 317 975 258 126 497 18 195 162 122 429 118 99 131 114 145 61 119 15 49 57 330 ## Sample-654 13275 2679 901 929 120 155 431 810 34 339 154 1762 144 65 158 17 22 115 49 59 48 130 104 311 35 47 49 18 37 26 26 ## Sample-655 29 4173 800 485 232 219 1885 525 94 128 189 11 146 108 525 17 248 141 217 354 59 53 90 112 63 33 71 24 54 34 44 ## Sample-656 46 8839 2445 1715 743 477 3694 1028 356 598 645 18 136 175 433 16 191 563 271 282 173 401 289 202 96 101 136 38 53 82 101 ## Sample-657 1453 6557 490 442 303 410 1829 1053 196 197 510 242 407 252 1073 15 769 75 497 832 77 83 136 277 461 72 103 15 39 58 81 ## Sample-658 65 2050 2693 1105 220 328 479 1379 88 393 138 23 109 127 695 15 333 118 166 50 200 213 159 165 175 35 243 17 42 76 46 ## Sample-659 1927 2442 1144 66 271 82 493 509 29 491 301 271 124 103 793 15 90 129 77 136 73 99 193 183 42 33 395 12 16 19 63 ## Sample-660 114 239 5064 2012 739 268 42 51 266 517 51 10 178 177 39 14 20 472 13 21 304 811 290 289 4 362 159 19 70 67 45 ## Sample-661 12240 2425 644 178 147 157 524 443 46 295 197 1579 172 64 250 13 214 73 67 273 74 160 67 116 68 34 48 14 20 34 230 ## Sample-662 250 4861 1826 2085 584 165 1060 162 373 568 254 22 123 117 273 15 1250 372 91 930 151 142 210 84 79 72 112 12 20 36 46 ## Sample-663 9508 1685 1698 1057 195 649 508 591 68 185 221 1861 113 86 195 14 25 72 87 132 132 84 119 277 49 56 34 21 21 56 90 ## Sample-664 20 6323 1265 2479 104 182 356 69 55 276 106 13 84 55 56 17 21 136 93 41 70 256 66 209 71 40 178 60 66 20 43 ## Sample-665 16 1539 2288 2939 136 164 322 41 39 227 107 14 144 101 364 17 22 99 52 62 143 166 121 117 21 87 156 18 66 39 48 ## Sample-666 38 6550 925 1021 339 169 825 114 63 109 414 16 117 56 273 16 285 32 173 235 51 45 51 84 236 20 288 13 9 16 32 ## Sample-667 11839 465 448 415 111 90 144 227 25 273 73 2138 93 187 38 16 22 30 34 48 242 96 123 42 35 71 27 12 22 32 48 ## Sample-668 10515 1442 964 170 110 100 605 80 56 249 144 1587 85 63 38 14 109 26 129 228 61 43 69 47 29 40 24 15 19 27 81 ## Sample-669 3815 5367 1166 1960 555 851 885 1968 143 1098 319 492 470 380 567 16 335 96 373 630 383 72 382 111 397 85 268 11 36 102 34 ## Sample-670 307 5973 1367 408 225 218 1318 1359 50 287 406 53 507 174 170 15 691 48 174 922 95 142 156 58 179 75 35 13 235 30 103 ## Sample-671 28 2719 384 1175 339 799 1189 680 83 158 426 13 108 83 951 16 524 66 261 505 118 82 176 120 53 38 114 252 55 49 41 ## Sample-672 663 1387 1820 1552 324 174 359 75 45 583 380 27 331 126 292 22 65 50 135 61 67 116 88 35 200 60 151 14 17 72 409 ## Sample-673 187 4723 93 486 319 406 870 1512 71 1025 1152 52 102 224 1321 15 138 50 312 257 51 113 420 74 125 49 105 12 70 26 18 ## Sample-674 31 2697 1444 2496 178 220 618 319 87 323 214 26 841 105 282 16 362 69 118 642 135 386 102 100 139 76 85 32 98 41 100 ## Sample-675 659 1502 1704 460 217 670 356 590 90 554 134 14 173 116 171 14 23 81 123 85 159 127 292 86 119 38 398 37 49 65 37 ## Sample-676 12093 1085 473 364 369 151 1238 741 183 338 139 1610 97 129 296 15 71 153 134 200 126 98 137 518 9 73 39 13 47 47 96 ## Sample-677 130 5869 236 1559 110 59 1874 124 92 255 361 21 47 56 104 14 807 22 138 251 52 70 59 54 13 29 26 10 11 24 95 ## Sample-678 14 1898 1640 652 411 484 570 314 231 224 182 9 334 112 298 14 360 38 223 338 105 87 102 134 335 58 179 39 24 66 421 ## Sample-679 107 2388 1011 1279 161 142 603 69 117 286 191 12 101 162 276 15 370 87 39 255 165 209 160 81 55 128 134 29 29 43 124 ## Sample-680 13 3988 726 2175 221 313 1146 2158 69 269 348 9 219 71 744 19 17 19 537 189 52 97 198 106 819 54 103 13 66 23 27 ## Sample-681 23 1447 3159 399 489 473 400 274 195 243 193 8 128 130 412 16 144 57 478 68 182 64 73 244 119 28 75 15 20 44 65 ## Sample-682 34 5546 267 283 181 143 984 537 124 101 272 7 57 74 54 12 442 35 218 223 63 53 57 107 120 33 13 11 38 27 20 ## Sample-683 245 2969 1651 1319 344 176 1198 442 290 113 198 11 65 110 208 15 20 236 103 132 113 49 141 70 89 50 62 13 16 33 30 ## Sample-684 14 1431 26 4982 156 21 173 89 109 2066 251 13 31 115 181 12 17 44 62 15 169 23 177 21 25 139 221 8 86 21 11 ## Sample-685 31 5994 626 2011 132 148 960 130 192 186 169 96 83 86 343 14 817 34 49 254 157 79 64 131 18 83 77 67 28 40 42 ## Sample-686 29 3811 311 649 150 254 825 423 46 217 214 7 78 91 929 12 231 83 70 143 101 32 95 105 23 46 311 13 17 21 17 ## Sample-687 7671 3958 1007 329 205 175 1015 223 49 107 234 1059 102 67 181 13 465 23 123 284 67 54 76 78 58 42 41 37 16 43 70 ## Sample-688 30 2464 147 1172 149 271 1261 582 81 107 303 9 101 84 124 15 534 157 162 507 37 99 140 26 177 36 34 30 46 26 31 ## Sample-689 26 7154 865 866 321 303 1019 1194 174 295 245 13 88 127 147 13 317 72 141 62 82 99 118 71 73 147 89 14 163 85 39 ## Sample-690 14 3937 966 3157 120 258 1252 495 81 366 359 10 188 91 743 15 447 93 93 85 82 299 113 59 78 80 121 11 24 60 387 ## Sample-691 109 4468 1123 569 182 283 630 1324 64 422 172 9 102 111 297 13 95 31 103 88 77 111 90 45 120 44 142 13 74 48 47 ## Sample-692 19 4299 934 1209 186 498 1095 109 49 137 339 12 133 58 792 14 229 24 235 680 36 14 34 100 266 58 208 11 18 59 23 ## Sample-693 246 4513 1169 612 253 310 1595 714 104 260 375 49 174 128 639 18 809 58 272 583 95 165 159 306 228 118 73 13 94 56 40 ## Sample-694 20 1549 2613 135 176 351 437 100 99 416 361 13 154 164 260 15 20 61 34 43 142 296 167 121 3 94 1925 15 124 57 50 ## Sample-695 17 5397 126 1909 329 1049 2354 1606 82 348 438 12 700 132 128 15 120 92 216 118 171 47 126 248 235 41 35 18 34 34 584 ## Sample-696 14 2372 1376 744 158 246 1098 400 106 280 338 12 516 147 600 16 430 88 206 200 81 107 100 70 159 52 272 24 81 59 81 ## Sample-697 30 614 3444 2539 788 365 169 44 329 1091 240 31 373 312 832 18 27 325 46 114 457 254 328 168 4 112 96 19 204 135 136 ## Sample-698 18 1897 757 4332 544 77 90 2059 97 962 577 20 83 157 561 22 29 81 59 24 131 117 182 288 41 51 129 13 19 38 21 ## Sample-699 10 44 134 143 2239 721 43 34 258 922 180 4 69 261 29 53 19 629 46 19 134 67 194 11 187 20 53 482 21 221 20 ## Sample-700 202 2604 2541 177 536 3266 633 1261 550 805 435 8 213 470 94 99 278 614 107 446 295 578 414 178 268 174 20 75 283 256 666 ## Sample-701 22 4828 754 5231 616 168 682 133 260 802 450 25 474 196 595 25 558 545 73 388 234 309 354 322 71 126 81 85 31 155 528 ## Sample-702 5056 959 163 61 253 81 800 706 13 59 185 961 23 26 100 26 71 12 131 34 20 17 24 114 11 15 23 13 8 9 15 ## Sample-703 19 229 126 28 311 27 330 904 9 27 120 4 137 37 184 15 39 10 162 43 12 23 12 19 26 10 12 10 8 15 27 ## Sample-704 16 334 252 84 70 44 296 207 15 42 76 5 18 28 696 16 2999 34 71 25 16 17 16 84 110 20 73 10 6 8 10 ## Sample-705 12 368 196 165 962 643 128 211 277 284 202 4 141 214 74 43 26 106 22 17 48 24 30 11 20 244 39 50 19 17 53 ## Sample-706 11 27 23 22 2095 19 33 20 51 139 240 3 260 444 11 64 20 31 11 17 25 23 43 9 3 32 7 17 11 231 31 ## Sample-707 11 1069 155 55 843 130 769 504 121 211 794 4 154 479 42 40 26 1058 912 50 40 33 74 82 496 45 10 24 346 30 71 ## Sample-708 30 84 1023 119 1008 295 205 1325 517 204 324 7 108 253 140 62 22 98 281 24 67 188 74 91 299 168 24 88 19 152 28 ## Sample-709 90 2291 5485 2966 378 305 134 40 412 648 740 51 239 201 312 246 17 157 26 61 363 182 392 131 4 52 314 116 21 83 39 ## Sample-710 26 1727 1343 2248 221 418 384 144 71 245 280 12 203 100 623 124 713 60 62 297 150 123 87 273 47 54 106 15 203 26 121 ## Sample-711 14 1830 541 738 135 206 269 75 109 142 95 6 97 54 272 31 80 154 39 49 45 90 43 115 44 58 71 45 29 26 28 ## Sample-712 7106 113 140 1177 343 32 30 23 80 275 110 1508 151 109 158 52 23 75 19 22 185 57 81 20 5 125 28 14 30 30 34 ## Sample-713 38 567 405 190 1161 430 262 630 415 143 187 11 86 172 224 224 51 166 299 48 47 98 73 55 135 79 75 40 67 106 28 ## Sample-714 27 1798 275 30 299 29 447 1979 11 27 58 7 36 88 50 18 1405 16 151 18 14 10 16 25 32 10 10 10 7 6 8 ## Sample-715 132 967 573 99 162 86 480 328 46 137 190 86 259 36 114 24 135 21 167 310 36 40 59 184 13 37 855 9 12 9 18 ## Sample-716 54 1384 418 51 170 58 446 685 39 82 152 39 150 24 75 18 100 15 148 435 25 22 38 129 5 22 401 7 8 7 14 ## Sample-717 5121 4697 766 48 901 892 1187 917 355 247 750 747 251 267 63 25 120 137 433 205 106 141 127 78 403 216 21 41 20 58 48 ## Sample-718 204 7725 390 107 200 166 1183 1103 68 111 475 38 66 78 68 534 152 30 88 440 32 36 78 65 17 41 199 11 9 43 19 ## Sample-719 2589 4955 409 412 201 85 1050 1569 25 79 321 492 181 35 74 42 95 14 116 286 26 20 30 391 41 21 339 17 5 11 15 ## Sample-720 13271 2915 1466 455 620 521 713 495 477 214 510 1832 278 419 36 183 1183 27 135 284 126 118 133 124 106 92 73 95 13 99 37 ## Sample-721 11056 2305 1041 78 320 138 363 1028 136 295 364 1705 334 154 60 50 47 46 69 98 51 140 111 173 64 122 237 13 19 40 123 ## Sample-722 8969 872 322 31 406 171 203 1588 148 309 403 1417 79 322 18 143 43 61 93 71 41 51 74 98 23 120 24 62 15 71 33 ## Sample-723 107 4279 365 469 476 963 764 310 329 111 691 10 146 135 96 493 399 36 214 155 47 55 63 38 60 39 29 27 11 43 26 ## Sample-724 823 5915 234 67 280 133 769 683 83 180 1349 223 67 68 70 76 20 18 87 296 33 36 63 32 27 106 34 12 14 30 30 ## Sample-725 155 5697 51 63 168 60 604 553 23 71 634 30 31 25 45 33 17 9 86 128 17 22 18 37 26 47 23 9 6 11 17 ## Sample-726 9456 392 1385 167 457 300 138 728 211 155 265 1505 177 189 49 22 19 23 29 30 54 67 94 40 30 138 33 110 14 67 33 ## Sample-727 149 3351 779 288 1118 873 977 522 284 286 1425 16 298 354 105 607 107 240 284 196 95 85 182 86 338 88 20 53 30 329 77 ## Sample-728 65 1890 1443 35 768 460 403 595 206 172 352 9 226 112 18 283 461 54 266 264 189 58 99 110 303 42 8 35 16 67 52 ## Sample-729 11243 200 1319 75 375 920 81 281 137 274 229 1454 271 331 17 24 43 29 33 35 52 64 90 64 19 97 14 364 18 92 57 ## Sample-730 9646 964 1647 136 544 398 235 1492 303 439 389 1525 185 331 52 57 54 53 47 33 56 218 123 45 45 270 109 19 32 135 35 ## Sample-731 9438 1055 506 168 201 118 113 766 103 155 146 1553 86 153 50 37 21 101 22 19 41 32 62 13 9 79 32 13 15 115 21 ## Sample-732 629 2201 387 33 661 1564 714 2528 332 211 671 75 92 480 47 116 137 58 151 175 73 64 153 29 17 177 22 17 19 143 40 ## Sample-733 2303 4309 579 161 237 110 903 267 112 201 780 480 100 58 112 24 792 20 180 426 57 55 71 134 243 59 45 23 22 43 29 ## Sample-734 11836 1123 1056 85 444 287 258 992 267 226 243 1806 292 156 49 62 70 49 121 45 43 80 92 84 189 45 560 42 25 92 71 ## Sample-735 2921 4973 617 118 894 433 494 736 805 514 1552 516 253 887 26 135 146 239 172 208 101 332 216 34 144 172 24 23 38 120 222 ## Sample-736 860 916 414 13 339 265 159 491 146 153 447 138 58 101 14 151 59 23 32 51 41 40 55 35 16 47 8 925 10 33 20 ## Sample-737 1933 291 263 2100 376 166 100 1424 60 250 148 256 184 123 209 205 22 61 159 33 60 25 67 116 93 23 205 46 25 37 21 ## Sample-738 37 163 69 1179 718 346 36 3021 74 170 192 40 74 120 219 61 18 23 91 17 43 14 37 13 5 19 85 13 8 14 15 ## Sample-739 688 525 300 63 328 179 103 1648 89 180 236 147 147 209 50 133 25 49 152 56 38 43 80 17 38 21 56 51 7 25 27 ## Sample-740 56 1355 492 3408 124 63 53 45 25 202 163 20 58 68 504 27 19 27 23 19 422 14 44 12 3 29 379 459 25 19 10 ## Sample-741 5797 432 320 860 375 379 258 3227 87 151 138 869 75 115 725 76 118 125 181 42 103 49 164 45 64 39 61 24 47 61 25 ## Sample-742 69 158 54 1565 425 328 39 3377 23 130 134 38 88 59 328 31 19 16 111 18 37 14 28 15 5 15 126 12 6 9 12 ## Sample-743 13509 131 183 2024 61 128 42 43 22 80 45 1972 329 40 52 27 17 18 12 16 29 41 42 9 3 20 176 9 6 26 25 ## Sample-744 935 548 305 119 463 224 131 2809 217 181 362 155 111 368 40 106 29 81 210 62 51 64 103 20 136 27 59 64 8 22 43 ## Sample-745 1994 1521 277 2637 183 202 270 866 95 240 183 286 98 83 877 37 18 30 68 51 86 27 69 98 44 47 361 168 85 58 16 ## Sample-746 125 1457 1161 2976 158 73 86 42 30 206 176 40 74 76 527 23 21 40 30 19 440 16 48 19 7 42 775 539 35 24 12 ## Sample-747 1960 506 176 487 292 734 506 3214 73 194 221 328 159 215 747 633 163 116 367 117 142 34 126 61 278 38 49 46 57 65 27 ## Sample-748 16 514 327 4882 119 425 283 76 110 273 149 45 57 52 1620 143 19 53 64 22 657 31 71 32 15 57 231 162 62 22 13 ## Sample-749 37 166 215 134 181 73 48 49 93 93 47 8 33 63 37 30 40 27 24 25 47 29 36 31 11 26 28 49 21 23 13 ## Sample-750 13 2751 470 291 477 534 675 299 204 450 514 6 297 182 85 21 95 118 222 206 261 248 166 190 39 127 42 109 31 54 37 ## Sample-751 17 3190 256 118 303 1008 1057 978 202 228 812 25 109 195 111 333 1123 37 332 303 49 104 110 76 300 46 26 28 45 65 25 ## Sample-752 12 27 24 38 1965 172 24 16 1369 247 158 3 192 523 16 206 21 98 12 17 198 42 145 10 9 731 11 635 104 381 46 ## Sample-753 14 639 1212 33 621 2020 354 107 199 266 310 4 773 195 99 355 791 217 124 64 362 131 217 114 35 122 39 81 198 260 61 ## Sample-754 12 248 2087 20 3969 1186 121 199 634 1122 269 3 207 371 15 90 21 276 141 133 125 392 412 109 78 448 8 43 249 93 243 ## Sample-755 13 666 788 247 2896 1408 500 1339 1213 285 295 4 434 431 37 370 20 210 509 183 117 305 400 191 761 232 13 162 113 381 423 ## Sample-756 14 1364 689 169 1584 1888 2124 360 884 164 708 4 258 279 75 261 83 282 477 618 78 695 176 86 341 296 17 112 43 249 66 ## Sample-757 177 1310 1214 874 1770 675 404 2438 1025 431 191 44 276 333 710 95 1225 207 291 94 171 251 245 82 289 454 73 36 160 124 57 ## Sample-758 70 1016 569 531 596 295 326 142 467 186 241 53 147 158 108 86 794 110 59 190 63 186 103 51 18 170 69 15 102 35 79 ## Sample-759 2365 262 2679 68 727 909 78 377 363 376 316 456 132 200 19 48 26 53 70 151 97 153 152 61 115 169 10 42 32 136 63 ## Sample-760 12 258 999 737 951 536 67 74 631 163 240 7 279 272 194 60 126 63 28 63 156 147 114 54 21 166 57 78 28 112 187 ## Sample-761 12 263 1650 15 494 2894 200 170 255 118 178 4 142 238 17 747 324 74 99 124 69 91 87 45 27 61 11 57 156 119 45 ## Sample-762 246 2080 1051 26 393 484 544 461 173 214 503 42 326 193 20 69 79 48 163 306 118 263 113 62 133 214 11 38 50 114 88 ## Sample-763 10 36 160 39 376 600 158 230 381 57 172 3 119 134 23 242 213 32 140 22 27 72 45 16 445 44 7 29 22 56 20 ## Sample-764 12 35 381 16 1669 1551 337 469 357 377 528 4 496 663 19 371 67 194 560 25 311 192 228 32 488 269 9 163 77 89 62 ## Sample-765 53 553 889 48 115 249 144 139 26 78 219 12 107 83 69 22 50 17 46 81 29 41 27 37 23 29 11 17 15 17 29 ## Sample-766 35 380 1519 158 778 332 166 233 655 418 253 6 281 201 92 50 527 145 125 85 152 255 120 507 91 151 30 110 64 46 84 ## Sample-767 15 280 215 25 557 475 672 572 417 185 544 5 226 287 18 380 101 179 995 186 151 374 89 114 655 133 11 304 204 34 42 ## Sample-768 12 723 1880 1022 691 296 265 108 477 480 294 6 138 176 286 179 27 259 53 183 158 64 209 181 125 79 32 43 26 84 35 ## Sample-769 9 134 440 64 387 624 241 189 51 180 187 4 34 95 19 486 509 28 65 39 60 17 55 117 32 15 16 16 18 9 11 ## ASV60 ASV52 ASV92 ASV23 ASV37 ASV4 ASV91 ASV62 ASV107 ASV19 ASV108 ASV20 ASV10 ASV57 ASV21 ASV104 ASV118 ASV115 ASV117 ASV34 ASV123 ASV100 ASV36 ASV47 ASV11 ASV58 ASV44 ASV22 ASV96 ASV90 ASV76 ## Sample-1 75 3 17 28 36 21 108 67 174 39 4 17 10 6 19 56 18 28 8 15 7 19 5 7 9 6 25 31 10 2 9 ## Sample-2 38 69 108 25 69 36 63 36 42 46 158 23 48 7 27 24 22 26 8 49 69 13 6 5 10 8 15 14 5 17 9 ## Sample-3 7 3 26 3 314 475 15 8 19 11 3 7 38 23 12 3 11 6 11 55 42 11 5 8 35 15 6 4 6 37 10 ## Sample-4 69 6 29 95 12 61 263 41 50 40 12 57 8 9 21 22 29 32 50 14 8 46 79 8 17 53 15 25 5 22 9 ## Sample-5 87 66 13 2 26 34 65 45 32 10 30 5 21 7 10 21 9 24 7 15 253 3 34 12 31 14 29 3 5 3 10 ## Sample-6 23 3 43 136 18 14 60 69 102 555 9 51 15 7 30 19 28 10 10 15 8 42 6 3 6 2 18 35 33 2 9 ## Sample-7 60 5 21 14 17 27 18 28 11 30 2 9 7 8 14 10 18 31 15 14 7 27 5 23 5 2 25 21 4 3 9 ## Sample-8 1592 2 6 0 18 21 30 27 78 5 127 3 11 38 8 14 5 25 5 21 7 2 6 4 14 2 46 5 11 2 10 ## Sample-9 5 3 6 0 99 78 7 7 287 5 7 3 15 9 8 9 5 45 5 24 8 2 5 3 51 2 253 3 4 6 10 ## Sample-10 188 4 15 17 32 169 37 30 14 24 4 14 10 7 13 15 15 11 5 17 10 20 7 6 31 3 13 8 4 8 11 ## Sample-11 199 2 9 2 65 438 14 10 16 6 16 4 23 7 9 7 5 16 24 83 10 3 5 17 58 3 49 3 5 16 10 ## Sample-12 172 3 6 3 21 31 17 11 25 8 4 3 19 7 9 6 5 115 9 16 7 1 5 9 12 3 126 3 4 4 11 ## Sample-13 51 47 79 44 24 27 38 53 71 163 73 44 11 8 31 15 28 33 26 20 8 52 13 9 7 6 9 10 4 6 10 ## Sample-14 36 3 9 53 38 38 115 42 36 15 7 5 9 14 11 20 7 123 10 34 8 3 5 3 15 637 5 5 4 3 10 ## Sample-15 162 2 6 2 23 100 179 17 18 5 4 3 9 6 8 9 5 10 4 13 7 2 5 17 40 2 109 4 20 4 9 ## Sample-16 91 4 14 12 51 164 17 16 42 18 3 10 9 9 18 10 17 39 28 17 8 45 5 5 97 2 27 7 4 3 12 ## Sample-17 595 2 7 1 134 128 430 13 43 5 10 4 16 7 9 10 5 141 12 15 7 2 5 39 32 3 105 3 5 8 11 ## Sample-18 347 3 14 7 61 41 6 11 52 12 15 5 12 7 12 14 8 18 10 16 8 7 6 3 44 2 76 4 4 7 12 ## Sample-19 229 6 15 22 13 95 39 58 28 35 3 20 12 7 18 22 22 6 6 14 7 42 6 15 15 4 7 9 4 13 11 ## Sample-20 225 2 21 25 96 75 133 40 39 20 37 11 45 7 14 27 10 27 7 17 7 8 35 30 44 3 7 6 5 9 11 ## Sample-21 336 2 6 2 13 54 37 20 106 6 62 3 11 6 8 12 5 50 5 13 6 2 6 15 23 18 65 2 13 4 9 ## Sample-22 975 2 5 1 843 346 10 15 24 5 6 3 10 7 8 21 4 5 5 119 7 2 5 13 179 3 72 3 4 25 15 ## Sample-23 133 3 64 33 15 27 30 58 71 57 27 18 22 9 29 13 35 73 20 16 8 18 16 11 18 18 7 12 19 6 10 ## Sample-24 65 15 80 89 17 164 58 22 60 40 44 37 18 40 38 31 36 16 26 23 8 46 14 7 34 4 12 19 19 15 12 ## Sample-25 59 7 115 36 15 203 43 127 143 30 45 10 11 8 26 18 30 17 17 18 9 20 14 7 17 16 12 8 6 9 11 ## Sample-26 67 2 82 87 11 193 33 48 98 80 6 37 17 7 39 13 34 68 34 14 7 59 18 3 8 4 12 9 4 9 9 ## Sample-27 36 5 15 4 19 12 19 18 33 15 3 42 9 8 15 10 13 25 18 18 9 7 6 91 8 5 19 7 12 3 16 ## Sample-28 46 13 13 3 13 8 18 28 26 13 8 18 23 7 14 11 11 36 7 20 48 8 6 60 14 89 2 6 14 5 13 ## Sample-29 64 3 38 14 15 23 38 42 33 10 5 10 16 7 13 13 15 35 7 16 8 5 10 66 13 28 47 7 4 8 12 ## Sample-30 56 5 7 1 44 33 30 18 130 6 8 4 16 8 10 10 5 8 6 19 9 2 33 603 24 10 5 3 4 7 11 ## Sample-31 66 4 11 2 49 88 126 21 97 7 12 6 11 14 12 12 7 30 6 65 16 3 29 144 51 54 39 4 4 10 33 ## Sample-32 141 6 24 51 42 46 183 66 209 32 529 12 28 35 23 33 9 45 13 46 26 5 87 480 55 771 60 8 5 16 13 ## Sample-33 5 255 180 407 12 57 73 10 8 217 5 153 13 61 35 7 97 4 20 25 10 98 7 4 8 3 3 35 6 8 12 ## Sample-34 13 5 38 6 23 53 20 45 23 112 33 16 47 192 53 14 32 13 44 32 15 14 25 6 32 5 28 14 28 24 18 ## Sample-35 15 3 124 141 10 16 10 83 16 123 3 22 14 7 33 19 63 48 21 16 8 111 12 5 7 4 12 102 15 6 11 ## Sample-36 2 27 17 21 10 35 312 6 6 720 2 9 15 2264 22 2 27 4 98 16 8 69 5 4 5 2 2 42 6 10 11 ## Sample-37 11 14 219 369 13 40 16 55 22 121 4 207 16 27 45 11 87 38 147 19 10 79 8 8 9 4 7 60 134 32 12 ## Sample-38 17 25 195 218 14 18 47 80 19 90 54 66 348 11 165 22 57 17 10 22 12 49 23 8 12 5 18 53 21 20 14 ## Sample-39 66 5 8 2 12 29 69 36 136 16 25 6 16 3035 11 10 7 224 21 14 7 5 4 47 14 5 4 6 4 6 9 ## Sample-40 28 37 32 35 21 14 32 23 57 25 5 18 26 8 15 16 15 23 7 16 13 3 6 35 14 6 15 10 12 3 10 ## Sample-41 12 63 16 21 21 723 134 10 18 10 4 10 14 73 14 9 9 129 6 16 147 5 5 150 35 2 4 5 3 3 10 ## Sample-42 30 113 59 170 20 39 59 83 16 67 7 60 14 8 40 27 45 37 19 18 167 24 9 70 21 3 64 23 4 6 10 ## Sample-43 37 5 33 27 20 76 30 38 31 41 138 21 19 8 29 8 26 50 30 19 12 16 12 33 12 18 29 8 4 5 10 ## Sample-44 39 4 8 4 15 14 54 145 77 7 116 7 10 7 9 51 6 9 6 15 11 2 10 4 13 10 10 3 4 6 10 ## Sample-45 149 863 20 4 12 28 202 185 151 15 171 9 9 7 12 33 10 33 19 16 8 4 27 60 17 15 7 4 4 3 11 ## Sample-46 57 43 15 23 24 33 111 159 57 19 19 19 13 7 12 255 10 96 32 19 7 10 26 32 8 40 13 14 4 7 11 ## Sample-47 49 100 11 2 23 34 73 150 92 13 64 12 9 7 11 31 7 28 9 14 8 3 41 23 11 47 20 4 4 7 10 ## Sample-48 128 2 10 1 17 44 209 240 53 7 131 6 12 7 10 94 7 18 20 15 11 4 67 19 14 39 4 4 5 6 13 ## Sample-49 29 42 7 1 15 61 139 168 183 7 10 5 13 7 10 74 5 19 8 15 8 2 26 58 7 11 28 3 7 9 16 ## Sample-50 12 4 10 0 162 247 18 16 29 8 6 4 38 7 10 10 6 7 7 50 8 2 5 104 27 21 8 3 5 12 10 ## Sample-51 6 3 7 0 625 24 8 9 75 6 6 3 10 8 9 7 5 59 7 31 7 2 5 289 30 4 3 3 4 15 14 ## Sample-52 173 10 18 1 84 50 241 125 77 12 46 7 36 9 13 123 9 41 15 51 8 5 17 67 18 25 47 6 4 15 13 ## Sample-53 23 3 7 1 340 27 8 8 13 5 15 4 10 7 9 5 5 7 6 102 24 2 5 323 18 6 10 3 4 8 80 ## Sample-54 66 16 15 2 28 28 53 130 116 15 71 19 27 7 12 97 9 24 13 25 12 6 22 55 11 14 13 6 8 7 12 ## Sample-55 53 6 15 26 13 18 41 192 20 25 24 13 8 6 12 104 9 9 6 14 7 5 8 20 9 23 57 14 5 6 9 ## Sample-56 22 28 6 0 81 53 133 252 71 5 57 3 80 11 10 82 5 106 6 68 8 3 43 48 30 74 12 3 8 13 11 ## Sample-57 40 3 56 37 20 31 52 69 104 50 71 23 77 7 23 109 24 25 33 17 7 12 10 37 16 57 30 10 10 20 14 ## Sample-58 26 6 7 1 9 24 79 41 198 6 13 3 7 6 8 26 5 9 5 13 7 2 17 4 9 3 32 3 3 4 9 ## Sample-59 36 3 54 17 14 9 38 175 148 53 24 30 10 7 24 30 18 36 12 15 7 15 27 23 9 53 24 27 10 2 10 ## Sample-60 15 13 14 4 20 41 17 21 37 12 12 9 19 7 12 13 8 42 9 17 9 5 6 30 18 18 6 5 21 17 10 ## Sample-61 103 3 26 9 26 34 197 35 202 15 97 9 63 8 15 23 17 14 10 23 9 11 23 51 22 13 34 11 7 15 11 ## Sample-62 44 12 15 4 12 36 57 25 12 9 65 7 10 7 10 19 8 11 9 18 7 5 17 29 9 24 5 4 4 7 10 ## Sample-63 73 10 13 4 12 53 521 120 352 7 154 7 151 14 11 139 8 194 6 16 8 5 297 55 34 6 49 5 16 9 11 ## Sample-64 131 4 43 103 50 26 52 47 52 28 21 19 14 8 21 13 16 48 9 28 15 15 52 8 13 3 28 30 4 9 13 ## Sample-65 173 107 10 16 110 41 43 169 178 11 37 10 15 8 12 76 8 10 15 58 51 6 23 10 22 23 15 12 4 14 22 ## Sample-66 164 90 75 66 41 80 68 95 46 45 197 35 49 10 80 51 33 10 36 22 38 34 42 5 15 22 18 13 4 42 15 ## Sample-67 80 4 38 77 87 16 29 29 59 22 49 82 147 10 25 11 22 12 14 78 38 13 36 13 21 32 14 20 21 9 13 ## Sample-68 111 2 22 17 27 111 46 72 109 19 8 31 12 7 12 25 12 28 6 23 14 5 22 11 11 9 10 11 4 9 10 ## Sample-69 100 7 30 52 136 300 44 48 79 20 20 23 48 8 20 24 15 93 7 23 8 7 11 104 40 6 4 12 38 80 13 ## Sample-70 112 6 39 33 53 73 67 31 61 20 5 17 29 13 22 13 26 20 26 40 12 10 13 5 18 12 34 8 11 9 16 ## Sample-71 176 3 62 60 77 55 163 129 35 57 48 38 40 10 41 123 49 32 20 50 14 27 136 7 18 26 54 34 20 16 14 ## Sample-72 506 3 11 29 96 42 107 33 39 29 13 15 11 8 13 105 15 33 6 24 8 10 6 18 9 3 81 14 4 5 12 ## Sample-73 10 13 39 20 230 155 33 13 91 32 17 14 57 8 27 5 27 7 10 161 18 12 43 3 43 11 9 7 10 45 10 ## Sample-74 139 3 48 16 39 90 77 104 180 40 14 12 33 8 23 51 18 68 20 17 10 15 45 7 16 18 21 9 5 11 11 ## Sample-75 201 6 13 30 15 25 93 202 50 13 7 41 9 7 14 43 12 10 5 15 7 7 30 8 9 12 46 11 4 7 10 ## Sample-76 149 6 10 4 37 38 212 56 89 14 67 7 31 8 11 11 7 10 6 19 56 3 22 102 45 56 20 4 4 6 11 ## Sample-77 122 5 14 20 56 54 40 16 62 20 10 18 101 7 20 8 14 6 8 16 18 8 45 28 26 58 14 9 3 16 9 ## Sample-78 62 4 26 37 68 51 131 27 81 20 38 19 51 18 16 9 14 20 6 50 13 7 8 14 16 22 16 17 4 15 12 ## Sample-79 226 56 96 42 55 71 48 65 30 75 10 25 67 8 28 53 24 48 16 18 16 19 6 12 15 22 16 14 10 6 16 ## Sample-80 58 7 29 20 44 28 28 29 22 18 74 16 17 7 25 15 18 7 13 31 12 14 9 3 11 7 7 7 11 15 10 ## Sample-81 114 3 36 15 357 569 21 12 88 40 10 15 31 13 34 6 27 6 6 145 9 24 17 23 82 6 7 11 6 30 11 ## Sample-82 153 3 16 7 398 93 12 62 20 9 581 7 9 7 12 16 8 53 7 17 9 3 44 49 51 98 4 4 5 15 9 ## Sample-83 84 3 48 55 12 27 35 151 139 43 10 48 14 7 30 18 20 10 31 15 8 19 41 6 17 23 7 12 17 6 10 ## Sample-84 175 4 18 24 41 19 62 50 127 13 19 17 17 9 16 23 15 15 7 28 34 6 16 20 15 21 26 12 8 5 16 ## Sample-85 205 3 25 19 23 19 22 132 55 22 96 11 13 8 16 36 16 13 8 23 9 8 16 4 7 26 26 14 4 4 12 ## Sample-86 90 35 14 13 49 139 20 12 132 17 6 7 12 14 13 8 8 9 6 16 8 3 5 29 20 10 7 5 4 12 11 ## Sample-87 147 7 39 35 36 87 30 28 79 23 44 27 22 7 20 34 19 11 10 19 11 15 25 13 14 7 23 11 5 19 10 ## Sample-88 193 4 19 18 46 71 44 49 93 29 150 18 20 10 26 11 17 18 13 28 13 9 19 17 63 42 4 11 17 14 14 ## Sample-89 42 11 17 5 36 16 27 34 28 15 9 12 156 7 15 10 11 65 13 16 21 9 9 4 13 10 5 14 15 13 10 ## Sample-90 177 2 84 128 24 67 128 46 121 25 8 31 40 7 24 6 26 9 14 20 8 13 7 4 19 6 15 29 62 33 16 ## Sample-91 213 9 14 60 21 27 22 48 33 18 15 18 16 8 13 20 10 14 6 24 8 6 27 6 12 3 16 10 7 4 11 ## Sample-92 200 4 13 13 75 63 183 27 60 33 22 13 11 8 17 16 10 84 6 28 29 6 53 4 58 23 11 6 8 13 39 ## Sample-93 72 56 13 4 47 40 49 92 38 11 19 37 12 7 13 36 11 10 6 20 7 3 13 3 10 9 7 6 4 7 10 ## Sample-94 76 6 41 27 206 132 14 23 140 28 8 26 18 12 24 11 21 96 10 37 17 7 7 4 69 4 7 15 12 9 28 ## Sample-95 148 190 13 8 73 57 101 18 50 14 7 34 14 8 13 111 13 98 14 22 9 5 8 6 16 25 32 5 6 11 12 ## Sample-96 133 3 18 44 30 60 34 80 45 39 8 9 14 7 13 20 11 12 9 17 7 7 27 12 11 8 31 6 12 11 10 ## Sample-97 385 5 8 6 64 61 32 148 187 9 6 6 9 8 11 32 6 90 32 25 8 4 29 4 10 11 19 5 11 11 11 ## Sample-98 96 2 17 6 44 192 102 29 128 14 6 10 27 7 14 11 11 10 6 17 8 4 29 3 26 3 11 13 10 14 10 ## Sample-99 202 6 61 72 30 72 64 164 63 92 10 38 23 13 59 71 31 19 24 23 18 20 42 5 20 26 27 17 9 14 15 ## Sample-100 209 99 17 25 44 50 72 54 42 24 11 175 14 9 23 32 27 199 29 35 13 12 14 19 13 5 26 14 5 10 13 ## Sample-101 262 161 36 90 149 95 42 155 72 35 13 32 18 10 15 60 19 22 9 28 10 8 11 48 14 3 23 16 5 19 13 ## Sample-102 414 223 18 11 30 22 68 93 142 17 12 153 10 8 15 106 10 28 8 18 8 6 8 31 8 33 17 23 4 3 15 ## Sample-103 138 139 13 15 39 41 26 36 62 12 22 10 30 9 15 27 9 14 8 20 10 5 30 14 24 6 4 14 5 8 13 ## Sample-104 414 6 64 64 332 74 64 61 32 65 103 125 120 12 145 22 64 18 29 77 114 13 30 5 123 117 53 61 43 31 19 ## Sample-105 82 8 99 314 135 534 47 13 131 80 10 82 47 27 44 7 41 70 11 67 35 20 16 7 33 33 24 23 18 35 11 ## Sample-106 109 208 30 23 50 55 66 46 70 44 28 91 150 8 32 16 26 8 28 29 34 27 35 18 30 25 14 11 8 46 12 ## Sample-107 69 67 40 227 69 97 53 141 107 63 42 42 13 9 30 59 30 36 23 27 10 21 7 29 30 51 21 42 12 8 13 ## Sample-108 163 7 19 4 141 41 297 45 114 18 36 12 27 9 15 38 14 12 13 36 14 7 32 28 30 36 16 6 16 26 13 ## Sample-109 171 3 25 5 44 33 93 31 20 18 478 12 17 11 18 69 18 27 7 20 22 8 68 9 37 30 9 11 7 9 11 ## Sample-110 99 3 14 3 158 80 52 49 94 12 25 7 65 8 14 58 10 12 7 39 14 6 8 62 32 36 9 5 5 22 11 ## Sample-111 178 5 24 36 16 51 160 162 77 29 50 21 12 8 16 168 13 14 8 19 10 8 35 10 13 13 30 21 4 6 13 ## Sample-112 77 10 58 57 37 92 73 237 43 32 13 49 13 7 20 42 25 16 16 22 8 12 27 21 15 17 16 10 20 11 11 ## Sample-113 58 4 75 10 18 43 96 146 43 13 15 14 46 7 18 29 44 11 34 22 11 13 31 12 12 12 15 15 17 17 11 ## Sample-114 16 3 44 6 30 25 27 58 65 14 25 19 18 8 16 17 11 10 8 34 9 8 6 10 11 7 4 6 5 11 12 ## Sample-115 51 9 38 26 27 44 83 47 26 17 136 13 36 7 16 26 13 6 17 19 21 12 28 6 23 35 15 13 4 20 11 ## Sample-116 40 83 33 32 26 63 58 30 30 16 8 21 12 7 24 38 19 49 52 17 10 8 15 16 24 20 23 8 7 11 11 ## Sample-117 23 7 64 72 29 27 53 37 14 24 10 30 52 9 29 18 20 10 24 28 15 17 24 12 15 7 41 17 5 21 14 ## Sample-118 31 53 29 21 18 30 126 78 99 17 22 14 27 9 18 29 16 13 12 29 12 7 40 14 14 15 86 15 5 14 13 ## Sample-119 57 73 17 19 22 33 101 58 83 10 83 12 19 8 13 39 13 32 17 22 31 4 6 54 19 26 16 6 4 5 10 ## Sample-120 48 20 30 2 33 139 75 51 15 13 31 9 95 7 16 24 13 18 9 40 13 12 26 17 31 15 8 5 4 41 10 ## Sample-121 91 265 31 38 16 198 174 101 129 16 148 19 93 8 19 48 19 23 11 17 13 12 16 38 21 20 28 11 5 27 11 ## Sample-122 42 2 41 9 13 44 88 99 41 13 131 12 36 7 15 50 18 7 8 16 14 6 17 13 11 13 29 6 7 16 10 ## Sample-123 31 17 5 0 11 41 22 14 30 4 5 2 65 6 8 62 4 8 5 15 8 1 12 25 87 11 4 2 3 4 10 ## Sample-124 64 3 11 3 14 24 33 103 26 7 123 5 11 7 10 22 6 9 6 15 9 2 13 52 23 34 14 4 5 8 12 ## Sample-125 73 246 11 10 16 51 55 110 36 12 18 10 15 7 11 126 11 46 6 15 25 3 11 20 17 7 76 4 3 7 10 ## Sample-126 513 3 9 4 14 50 114 58 179 7 759 5 15 7 10 51 5 29 8 17 8 2 8 30 16 7 57 4 4 5 10 ## Sample-127 71 8 22 17 60 323 129 70 75 36 28 15 67 8 18 32 14 65 19 29 10 6 7 11 14 20 46 26 5 37 11 ## Sample-128 93 77 18 16 106 74 147 39 17 13 5 17 47 7 13 20 11 8 6 44 23 6 16 11 26 15 35 28 4 15 11 ## Sample-129 139 3 39 35 26 51 62 289 65 51 71 98 20 8 27 430 24 18 9 74 8 19 25 37 11 18 22 16 11 8 15 ## Sample-130 82 6 17 4 19 28 96 62 72 10 140 6 27 8 12 40 7 236 6 16 11 4 28 27 25 15 22 6 9 9 11 ## Sample-131 173 4 9 1 121 32 143 160 244 7 159 5 28 8 9 83 6 64 8 79 13 2 42 31 24 35 8 4 4 4 18 ## Sample-132 82 73 30 47 26 35 329 147 22 17 72 11 9 7 10 119 8 77 7 21 8 3 5 3 6 3 127 8 4 3 10 ## Sample-133 77 15 17 3 117 26 55 95 23 11 9 9 94 20 15 36 12 12 15 28 11 6 6 9 16 19 7 6 15 16 12 ## Sample-134 211 5 21 49 14 67 44 206 34 29 69 25 19 7 32 56 24 16 11 16 7 6 25 6 30 4 20 10 33 25 9 ## Sample-135 125 3 25 16 20 84 303 178 119 15 330 13 53 11 12 70 14 26 25 21 8 4 18 27 33 15 79 7 6 16 12 ## Sample-136 84 2 33 12 157 93 60 62 58 24 11 43 21 7 30 47 19 78 10 35 9 9 46 26 15 26 38 12 8 16 22 ## Sample-137 57 3 90 49 19 84 245 84 73 37 21 48 59 8 27 41 32 7 55 19 160 12 157 6 23 17 13 13 22 44 12 ## Sample-138 57 5 47 48 12 190 154 164 68 25 190 49 57 8 59 39 26 45 39 16 11 22 22 16 20 23 17 29 5 34 12 ## Sample-139 128 41 46 54 30 78 120 110 137 155 9 21 10 8 33 104 29 44 17 16 9 53 6 9 10 8 23 13 3 8 12 ## Sample-140 66 117 25 87 40 326 69 65 72 26 8 36 67 10 43 24 26 41 21 30 46 25 14 9 27 21 6 19 6 13 12 ## Sample-141 219 31 33 14 30 18 97 153 165 11 31 10 10 8 14 102 13 36 7 19 8 4 22 31 20 17 48 5 5 9 12 ## Sample-142 48 3 43 19 40 378 101 44 36 28 10 79 67 18 19 31 27 10 18 40 16 16 8 16 18 11 16 16 9 33 10 ## Sample-143 17 4 23 5 13 49 30 78 18 15 25 12 20 10 17 27 19 6 11 22 13 7 12 10 9 9 12 9 8 8 13 ## Sample-144 66 2 7 2 21 40 62 185 37 5 6 4 11 6 8 75 5 14 5 19 8 2 24 10 9 10 13 3 3 7 9 ## Sample-145 59 3 18 15 13 73 131 120 178 12 34 11 52 8 12 61 11 30 10 17 24 6 15 6 15 29 58 6 4 16 12 ## Sample-146 32 2 40 14 12 64 52 38 15 35 127 22 46 7 23 16 35 10 40 15 25 21 114 4 20 51 5 8 16 49 10 ## Sample-147 122 2 28 41 53 23 73 63 65 35 19 16 16 7 17 143 13 37 12 22 8 10 12 9 13 14 33 22 5 4 12 ## Sample-148 149 3 51 94 42 85 164 33 82 54 327 49 150 11 34 41 25 33 11 52 9 17 14 77 25 13 18 15 10 33 14 ## Sample-149 18 3 11 7 14 17 26 40 26 11 193 8 32 7 13 20 7 15 13 15 11 3 9 7 10 6 7 6 5 5 9 ## Sample-150 15 30 51 13 14 17 33 96 43 20 6 15 9 12 16 92 21 35 17 17 8 13 5 16 9 9 8 9 4 10 11 ## Sample-151 38 189 58 51 10 86 35 25 45 64 4 24 38 8 33 19 38 9 16 18 13 18 26 14 12 4 6 9 4 23 11 ## Sample-152 151 80 10 8 34 18 53 60 63 15 98 14 9 7 12 12 9 25 6 26 9 7 24 24 13 24 3 7 6 5 11 ## Sample-153 74 543 40 36 16 16 47 27 88 16 8 20 20 7 17 24 17 41 8 16 12 6 41 24 14 11 14 10 4 3 11 ## 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Sample-621 1 7 6 3 4 67 3 7 4 7 5 6 4 5 5 4 1 6 1 3 2 1 2 2 2 1 2 2 2 1 2 ## Sample-622 1 7 6 3 4 6 3 9 5 7 5 4 4 2 5 4 1 13 2 2 3 1 2 3 6 1 2 2 2 1 2 ## Sample-623 96 8 5 69 4 6 3 3 5 12 6 2 4 4 2 4 7 7 1 2 2 1 2 3 4 2 2 2 2 1 2 ## Sample-624 2 9 6 4 4 52 4 6 5 11 6 4 5 7 7 5 1 4 4 2 3 1 3 3 3 2 3 3 3 1 3 ## Sample-625 1 9 6 4 4 25 4 5 5 5 6 2 5 3 4 5 1 8 1 2 3 11 2 3 3 1 3 3 3 1 2 ## Sample-626 1 9 6 4 4 39 3 4 4 9 5 6 5 3 3 4 1 6 2 3 3 1 2 3 3 2 2 3 2 1 2 ## Sample-627 1 10 7 4 5 12 4 7 5 7 6 3 6 3 4 5 1 5 2 2 3 1 4 3 3 2 3 3 3 1 2 ## Sample-628 1 8 6 3 4 16 3 4 4 5 5 3 4 4 3 4 0 3 3 4 2 1 2 3 3 1 2 2 2 1 2 ## Sample-629 1 7 7 3 4 4 4 2 3 9 5 2 4 2 2 4 0 2 7 2 2 1 2 2 2 1 2 2 2 1 2 ## Sample-630 1 7 5 3 4 8 3 3 3 4 5 2 4 3 2 4 0 3 4 11 2 2 4 3 2 1 2 2 2 1 2 ## Sample-631 1 7 5 3 3 1 3 2 3 6 4 2 4 4 2 4 1 2 25 4 2 1 2 2 1 1 2 2 2 1 2 ## Sample-632 1 6 7 3 3 4 3 3 3 2 4 2 4 2 2 4 0 1 1 1 2 1 1 2 2 1 1 2 2 34 1 ## Sample-633 183 7 9 87 4 16 4 3 4 3 5 2 4 2 3 4 0 2 3 3 2 1 2 2 2 1 2 2 2 15 2 ## Sample-634 1 11 5 3 4 7 3 4 4 15 5 3 4 2 2 4 2 3 2 2 2 1 2 2 2 1 2 2 2 1 2 ## Sample-635 1 8 6 4 4 4 4 3 4 4 5 2 4 2 3 5 0 2 1 5 2 1 2 3 3 1 2 2 2 1 2 ## Sample-636 1 8 6 5 4 29 4 3 4 6 5 2 5 3 3 4 0 4 8 2 2 1 2 3 3 1 2 2 2 1 2 ## Sample-637 1 7 18 4 4 4 6 4 3 2 5 5 4 7 3 4 0 2 2 1 2 1 2 2 2 4 2 2 2 1 2 ## Sample-638 2 7 5 3 4 19 3 5 3 3 5 3 4 4 3 4 0 3 4 2 2 1 2 2 2 2 2 2 2 1 2 ## Sample-639 1 9 7 13 4 17 4 4 6 7 5 5 5 2 3 4 0 8 7 2 2 6 3 3 4 1 3 2 2 1 2 ## Sample-640 1 8 7 3 4 96 5 5 5 7 5 3 5 3 3 4 0 6 15 7 2 2 2 3 3 1 2 2 2 1 2 ## Sample-641 1 8 7 3 4 27 4 2 4 26 5 3 5 3 2 4 0 5 3 2 2 1 3 3 4 1 2 2 2 1 2 ## Sample-642 1 8 7 4 5 7 4 3 6 3 6 3 5 3 3 5 3 8 2 4 3 1 2 3 5 1 2 2 2 1 2 ## Sample-643 1 8 9 4 4 44 4 3 4 14 5 3 4 3 3 4 0 3 6 19 2 1 3 3 3 1 2 2 2 1 2 ## Sample-644 1 7 7 3 3 6 3 3 3 6 4 2 4 3 2 4 0 2 9 3 2 1 2 2 2 1 2 2 2 2 2 ## Sample-645 1 7 5 6 3 2 3 2 3 3 4 2 4 3 2 4 0 2 2 1 2 2 2 2 2 3 2 2 2 1 1 ## Sample-646 1 6 5 3 3 3 3 5 3 16 4 2 4 1 3 4 0 4 2 8 2 1 1 2 3 1 2 2 2 1 2 ## 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Sample-660 1 7 6 4 4 4 3 2 3 2 5 3 4 3 3 4 0 2 0 1 2 1 2 2 2 1 2 2 2 1 2 ## Sample-661 1 7 6 3 3 2 3 2 3 5 4 2 4 5 2 4 0 3 6 4 2 1 3 2 2 2 2 2 2 1 1 ## Sample-662 1 8 6 3 4 3 4 4 4 4 5 3 5 2 3 4 0 3 3 8 2 1 7 3 4 1 2 2 2 1 2 ## Sample-663 1 7 5 3 3 3 3 3 3 3 4 2 4 3 2 4 0 3 1 1 2 1 2 2 2 5 2 2 2 1 2 ## Sample-664 1 8 7 3 4 43 4 3 3 4 5 4 4 4 3 4 0 3 2 16 2 1 2 2 3 1 2 2 2 1 2 ## Sample-665 1 9 7 4 5 16 4 4 4 12 6 3 5 43 3 5 1 2 1 2 3 1 2 3 2 1 2 3 3 1 2 ## Sample-666 1 9 6 3 4 3 3 3 4 6 5 2 5 3 3 4 0 6 1 5 2 1 2 3 3 1 2 3 2 1 2 ## Sample-667 38 8 6 5 4 3 3 6 4 3 5 2 5 4 3 4 1 2 0 2 3 1 2 3 3 1 2 3 3 1 2 ## Sample-668 1 7 6 4 3 2 3 2 3 3 4 2 4 4 2 4 2 5 3 3 2 1 3 2 2 2 2 2 2 1 1 ## Sample-669 442 8 9 4 4 6 4 8 6 9 5 2 5 2 4 4 1 5 22 2 2 1 2 3 4 1 2 2 2 1 2 ## Sample-670 56 8 6 162 4 8 4 2 5 24 5 2 4 2 2 4 3 9 6 1 2 1 5 3 4 4 2 2 2 8 2 ## Sample-671 1 8 6 4 4 3 4 3 5 5 5 9 5 6 3 4 0 6 4 2 2 2 2 2 5 4 3 2 2 1 3 ## Sample-672 2 9 7 4 5 10 4 4 5 4 6 3 6 4 3 5 1 3 3 3 3 1 3 3 3 1 3 3 3 2 2 ## 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Sample-699 1 1004 11 3 4 1 10 4 4 2 17 33 7 156 3 4 1 2 0 3 3 2 2 2 4 1 2 2 2 1 2 ## Sample-700 1 9 15 3 4 1 5 3 10 6 5 7 4 3 2 4 0 5 1 1 2 2 2 2 3 1 2 2 2 1 2 ## Sample-701 1 7 9 3 4 16 4 3 4 10 5 7 4 2 2 4 0 6 24 5 2 1 2 3 3 1 2 2 2 1 2 ## Sample-702 3 10 8 4 5 1 4 3 5 3 7 3 7 3 3 6 1 3 8 2 3 2 3 4 3 2 3 3 3 1 3 ## Sample-703 1 6 7 3 3 0 4 2 3 2 5 2 4 1 2 4 0 4 5 1 2 1 1 2 2 1 2 2 2 1 2 ## Sample-704 1 8 6 3 4 1 3 2 3 2 5 2 5 3 2 4 0 3 2 2 2 1 2 2 2 1 2 2 2 1 2 ## Sample-705 1 8 5 3 4 1 3 3 4 3 5 3 4 2 3 4 14 2 2 5 3 1 2 3 2 1 2 2 2 1 2 ## Sample-706 1 7 5 3 8 0 3 4 4 2 5 4 4 2 3 4 0 2 0 2 3 1 2 2 2 1 2 2 2 1 2 ## Sample-707 1 8 8 3 5 2 4 6 6 2 5 3 5 2 4 4 1 7 0 4 4 2 2 2 3 1 2 2 2 1 2 ## Sample-708 1 10 12 5 5 1 9 5 9 3 11 5 5 2 3 5 21 3 1 2 3 2 8 3 3 2 3 3 3 1 3 ## Sample-709 1 7 9 5 3 12 4 3 4 2 4 8 4 19 2 4 0 2 3 3 2 1 3 2 3 1 2 2 2 1 2 ## Sample-710 1 8 7 3 4 8 4 5 4 5 5 3 5 2 3 4 0 2 41 18 2 1 2 2 2 1 3 2 2 1 2 ## Sample-711 2 8 6 4 5 8 4 4 4 3 6 4 5 2 4 5 1 3 3 5 3 2 2 3 2 1 2 3 3 1 2 ## Sample-712 1 9 16 17 5 2 6 5 4 3 6 3 6 3 4 5 1 2 5 4 3 1 2 4 3 1 2 3 3 1 2 ## Sample-713 2 14 12 6 8 4 6 10 7 4 9 5 9 3 6 8 1 7 7 5 5 2 4 5 4 3 4 5 5 2 4 ## Sample-714 1 7 5 3 3 0 3 2 3 3 5 2 5 2 2 4 0 2 0 2 2 1 1 2 2 1 2 2 2 1 1 ## Sample-715 75 7 12 23 8 3 11 2 6 3 5 2 4 3 2 4 1 10 5 2 2 1 11 5 4 1 5 4 2 1 3 ## Sample-716 68 6 5 12 5 3 3 2 6 2 5 2 4 2 2 4 1 8 3 1 2 1 7 7 3 1 2 2 2 1 2 ## Sample-717 2 8 10 14 232 1 6 2 10 5 5 10 4 19 2 4 5 4 2 2 2 4 2 3 4 1 5 3 2 1 2 ## Sample-718 189 8 11 39 4 6 4 3 8 4 5 3 4 2 2 5 9 7 2 2 2 1 4 3 3 3 2 2 3 1 2 ## Sample-719 97 7 7 128 4 3 4 2 4 4 5 3 4 3 2 4 1 8 1 1 2 1 6 3 4 1 2 2 3 1 2 ## Sample-720 44 7 14 46 5 3 6 3 8 5 5 5 4 6 2 4 3 11 1 1 2 2 3 8 3 3 3 2 2 1 2 ## Sample-721 160 8 13 128 4 2 5 2 6 5 5 4 4 3 2 5 6 8 3 2 2 1 12 3 3 5 2 2 2 1 2 ## Sample-722 394 6 7 182 3 1 3 2 8 2 4 10 4 12 2 3 2 17 0 1 2 3 2 2 2 39 2 2 2 1 1 ## Sample-723 5 8 36 31 5 6 22 4 18 3 5 9 4 5 2 4 2 10 5 2 2 81 2 8 4 16 3 3 2 1 3 ## Sample-724 190 8 7 129 4 2 3 2 8 2 5 6 4 6 2 4 1 3 2 1 2 1 4 4 4 6 3 2 2 1 2 ## Sample-725 105 6 5 135 3 2 3 2 4 1 5 5 4 3 2 3 0 2 1 1 2 1 1 4 3 1 3 2 2 1 1 ## Sample-726 1 7 15 7 4 3 6 4 4 3 5 5 4 7 2 4 0 2 1 1 2 1 2 3 2 1 2 2 2 1 2 ## Sample-727 2 8 10 37 4 3 4 3 12 9 5 9 4 3 2 4 3 3 6 2 2 1 2 6 3 3 5 2 2 1 2 ## Sample-728 2 6 8 35 3 0 4 3 8 2 5 8 4 5 2 4 2 2 1 1 2 2 1 7 2 3 6 2 2 1 2 ## Sample-729 102 7 65 76 11 1 32 3 7 2 8 7 5 8 2 4 8 5 0 1 2 6 2 2 2 1 2 2 2 1 3 ## Sample-730 127 7 19 13 4 3 7 3 6 3 6 7 5 5 3 4 3 3 1 2 2 1 2 3 3 2 3 5 2 1 2 ## Sample-731 279 6 8 8 3 3 6 2 4 2 5 5 4 6 2 3 1 2 1 1 2 1 1 2 2 1 2 2 2 1 2 ## Sample-732 19 11 9 49 4 1 4 4 13 2 5 3 4 11 3 4 7 8 1 1 2 1 2 2 4 1 3 2 2 1 2 ## Sample-733 7 9 9 18 7 3 5 3 6 3 12 12 5 16 2 5 3 4 3 2 2 1 2 5 4 1 4 3 3 1 2 ## Sample-734 21 7 7 71 6 2 5 2 6 4 5 6 4 11 2 4 1 13 1 1 2 1 2 3 2 2 2 2 2 1 2 ## Sample-735 229 7 8 37 4 1 4 3 10 2 5 3 4 3 2 4 10 16 1 1 2 1 2 5 3 3 3 2 2 1 2 ## Sample-736 120 7 61 356 692 0 51 2 6 2 4 22 4 71 2 4 2 2 0 1 2 7 2 5 2 2 3 2 2 1 5 ## Sample-737 1 9 8 9 4 32 4 4 5 2 5 4 5 4 3 5 2 5 2 2 5 1 2 4 2 1 5 3 3 1 2 ## Sample-738 2 7 26 49 4 3 16 3 4 2 5 6 6 2 2 4 20 2 1 1 5 1 2 33 4 1 3 2 2 2 2 ## Sample-739 1 9 9 8 4 0 4 4 4 4 5 4 5 5 3 4 164 4 10 2 5 1 2 3 3 1 3 2 2 1 2 ## Sample-740 2 10 7 67 4 37 4 7 3 3 5 25 4 2 3 4 2 2 3 2 4 1 2 6 2 1 2 2 2 1 2 ## Sample-741 1 8 6 13 3 3 3 4 4 2 5 4 4 2 3 4 19 2 1 1 2 1 2 4 2 1 3 2 2 1 2 ## Sample-742 2 7 32 43 4 4 21 2 4 2 5 5 7 2 2 4 7 2 1 1 3 1 2 31 4 1 2 2 2 2 2 ## Sample-743 1 6 97 3 3 4 26 4 3 1 4 2 4 3 2 4 2 2 0 1 2 1 3 5 5 1 2 2 2 1 2 ## Sample-744 1 8 10 6 3 1 4 4 4 3 4 4 4 4 3 4 209 4 6 1 7 1 2 3 3 1 3 2 2 1 2 ## Sample-745 1 8 14 239 4 8 6 7 4 2 4 21 4 10 3 4 2 7 4 1 2 1 2 4 5 1 3 2 2 1 2 ## Sample-746 2 12 10 20 4 78 4 17 3 3 5 29 4 2 5 4 2 2 4 2 9 1 2 6 2 1 2 2 2 1 2 ## Sample-747 1 10 8 23 4 3 4 4 12 2 5 8 4 2 3 4 9 3 2 2 2 1 3 4 3 1 5 2 2 1 2 ## Sample-748 1 7 7 3 4 33 3 6 3 2 5 7 4 8 3 4 1 2 1 2 3 1 4 2 2 1 3 2 2 1 2 ## Sample-749 1 7 5 3 5 3 6 4 3 2 4 3 4 2 4 4 0 2 0 2 5 1 2 2 2 1 1 2 2 1 1 ## Sample-750 1 10 7 3 4 3 5 4 4 5 5 4 4 2 6 4 1 6 0 2 3 1 2 2 3 1 2 2 2 1 2 ## Sample-751 11 9 12 7 8 1 12 6 6 4 5 3 4 2 3 4 1 6 1 2 4 4 2 10 3 1 3 2 2 1 2 ## Sample-752 1 12 9 3 9 0 6 14 4 2 4 12 4 16 6 4 1 2 0 1 5 5 1 2 2 1 2 2 2 1 2 ## Sample-753 1 8 8 3 4 2 6 30 4 27 5 5 4 3 22 4 2 2 1 6 3 1 2 2 3 2 4 2 2 1 2 ## Sample-754 1 8 8 3 4 1 5 22 6 5 5 4 5 2 11 5 2 3 0 2 3 3 2 2 3 1 2 3 2 1 2 ## Sample-755 1 8 9 3 4 1 5 32 5 2 5 10 4 2 8 4 2 2 0 2 3 1 2 3 3 1 3 2 2 1 2 ## Sample-756 1 9 9 3 4 1 6 6 5 2 5 7 4 5 6 4 1 4 0 2 3 1 2 2 3 1 3 2 2 1 2 ## Sample-757 1 8 8 4 5 10 6 8 4 9 5 3 5 3 4 4 1 4 1 2 3 2 2 3 4 1 2 3 3 1 2 ## Sample-758 1 8 7 3 6 13 6 8 4 5 5 3 4 4 4 5 1 4 2 13 2 1 2 3 4 1 2 2 2 1 2 ## Sample-759 1 9 15 16 29 0 11 3 10 3 6 4 5 2 3 5 16 3 0 2 3 5 2 4 3 1 3 4 3 1 3 ## Sample-760 1 9 8 3 4 7 4 7 4 3 5 3 4 7 3 4 0 2 1 1 2 1 2 2 2 1 2 2 2 1 2 ## Sample-761 1 9 9 3 5 0 5 11 4 2 5 4 7 2 5 4 1 3 0 2 3 2 6 3 3 1 2 2 2 1 2 ## Sample-762 1 7 6 3 4 0 4 3 7 11 5 3 4 34 3 4 3 2 0 2 2 1 2 3 3 1 2 2 2 1 2 ## Sample-763 1 6 6 3 3 0 3 5 3 2 4 3 4 1 4 4 1 2 0 2 2 1 2 2 2 1 2 2 2 1 1 ## 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Sample-753 0 0 0 0 0 0 ## Sample-754 0 0 0 0 0 0 ## Sample-755 0 0 0 0 0 0 ## Sample-756 0 0 0 0 0 0 ## Sample-757 0 0 0 0 0 0 ## Sample-758 0 0 0 0 0 0 ## Sample-759 0 0 0 0 0 0 ## Sample-760 0 0 0 0 0 0 ## Sample-761 0 0 0 0 0 0 ## Sample-762 0 0 0 0 0 0 ## Sample-763 0 0 0 0 0 0 ## Sample-764 0 0 0 0 0 0 ## Sample-765 0 0 0 0 0 0 ## Sample-766 0 0 0 0 0 0 ## Sample-767 0 0 0 0 0 0 ## Sample-768 0 0 0 0 0 0 ## Sample-769 0 0 0 0 0 0 ## [ reached getOption("max.print") -- omitted 382 rows ] ``` --- ### Principal Components Analysis Principal components analysis (PCA) gives an low-dimensional overview of the entire community. It searches for views that maximize variance. <div style="text-align: center;"> <img src="figures/pca_q1.png"/><br/> What is this object? </div> --- ### Principal Components Analysis Principal components analysis (PCA) gives an low-dimensional overview of the entire community. It searches for views that maximize variance. <div style="text-align: center;"> <img src="figures/pca_q2.png"/><br/> Not so complicated now. Credit for this example goes to Julie Josse. </div> --- ### Principal Components Analysis You can think of each sample as a high-dimensional vector across taxa. PCA finds a low-dimensional view of those high-dimensional vectors. <div style="text-align: center;"> <img src="https://github.com/krisrs1128/stat436_s24/blob/main/exercises/figure/pca_projection.png?raw=true" width=800/> </div> --- ### Scree Plot The principal components are sorted according to the amount of variance that they explain. Pay attention to steep dropoffs -- these might suggest true numbers of communities. <div style="text-align: center;"> <img src="figures/pc_eigenvalues.png" width=800/> </div> --- ### Resulting "Maps" The samples are organized so that those with similar measurements are placed close to one another. Different dimensions give different views. <div style="text-align: center;"> <img src="figures/pc_scores_1-2.png" width=1200/> </div> --- ### Resulting "Maps" The samples are organized so that those with similar measurements are placed close to one another. Different dimensions give different views. <div style="text-align: center;"> <img src="figures/pc_scores_5-6.png" width=1200/> </div> --- ### Components The PCA components give a way of interpreting the axes of the map. The further we move in the PC1 direction, the more we increase the positive PC1 taxa, and vice versa for negative taxa. <div style="text-align: center;"> <img src="figures/pca_loadings_grid.png" width=1100/> </div> --- ### PCA Interpretation <div style="text-align: center;"> <img src="figures/focus_pc_1.png"/> </div> --- ### PCA Interpretation <div style="text-align: center;"> <img src="figures/focus_pc_2.png"/> </div> --- ### Identifying Dimensions Interesting variation can be buried in higher components. A ridgeplot [14] can help identify these. <div style="text-align: center;"> <img src="figures/pc_ridge-4.png" width=1200/> </div> --- ### Topic Models <div style="display: flex; justify-content: space-between; align-items: center;"> <div style="flex: 1; padding-right: 20px;"> 1. Since components can have both positive and negative values, effects in PCA can cancel out, complicating interpretations.<br/><br/> 2. Topic models deal with this by requiring components to be nonnegative [15; 16]. Therefore, they can be interpreted as latent communities [17]. </div> <img src="figures/latent_dirichlet_v2.png" width=600/> </div> --- ### STRUCTURE Plot The mixtures across the entire dataset can be visualized in stacked barplot. This dataset studied community dynamics after antibiotics treatment [18]. <div style="text-align: center;"> <img src="figures/antibiotic_memberships.png" width=2000/> </div> --- ### Topics We can also visualize the topics themselves. It helps to sort the taxa so that those that have the highest variation across topics are shown first. <div style="text-align: center;"> <img src="figures/antibiotic_superheat.png" width=1000/> </div> --- ### Topics We can also visualize the topics themselves. It helps to sort the taxa so that those that have the highest variation across topics are shown first. <div style="text-align: center;"> <img src="figures/beta_representatives.png" width=1000/> </div> --- ### Alto Plot The main hyperparameter in topic models is the number of topics `\(K\)`. We wrote a package to make it easier to compare results across `\(K\)` [19]. <div style="text-align: center;"> <img src="figures/alto_sketches_annotated alignment.png" width=940> </div> --- ### Alto Interpretation <div style="text-align: center;"> <img src="figures/pregnancy_sankey.jpg" width=500/><br/> Figure from [20]. </div> --- ## Integration --- ### MA Plot - Revisited .pull-left[ 1. MA plots are often helpful for identifying sources of technical variation, like batch effects. 1. The example shown here compares microarray data from experiments that are identical except for the choice of dye [21]. ] .pull-right[ <div style="text-align: center;"> <img src="figures/dye_effects.png" width=400/> </div> ] --- ### CCA Biplots Canonical Correlation Analysis (CCA) builds PCA-like maps for each dataset so that they look as similar to one another as possible. <div style="text-align: center;"> <img src="figures/sparse_cca_multitable.jpg" width=980/><br/> Figure from [22]. </div> --- ### CCA Components Like in PCA, the directions in a CCA plot can be interpreted by analyzing the CCA components. Each data source has its own set of CCA components. <div style="text-align: center;"> <img src="figures/sparse_cca_multitable.jpg" width=980/><br/> Figure from [22]. </div> --- ### Considerations 1. Like with ECDF plots, the output from a dimensionality reduction will depend on initial original data transformations. 1. When there are many more features than samples, PCA and CCA can be unstable. Regularized versions, like the sparse PCA and CCA we used here [23], can be more stable [24; 25]. 1. CCA searches for shared variation across tables. This can cause the results to ignore table-specific variation. To decompose variation into shared and distinct components, consider methods like [26; 27]. --- ### Mediation Analysis 1. If we have precise hypotheses about how datasets might be related, we can design visualization to evaluate them. 1. For example, in mediation analysis, expect the treatment to affect an omic dataset indirectly through an intermediary [28; 29]. <div style="text-align: center;"> <img src="figures/mediation_diagram.jpg" width=500/> </div> --- ### Mediation Analysis This faceted plot shows the paths with the strongest indirect effects in joint metabolome-microbiome analysis [30]. <div style="text-align: center;"> <img src="figures/mediation_scatterplot.jpg" width=900/> </div> --- ### Conclusion 1. Visualization is helpful throughout the data analysis process -- validation, discovery, and communication. 1. Other helpful visualization in microbiome research are heatmaps [31], residual plots [32], partial dependence [33; 34], phylogenetic [35], and network visualizations [36; 37]. 1. The best visualizations are the product of repeated refinements, just like the best writing. --- .center[ ### Thank you! ] * Contact: ksankaran@wisc.edu * Materials - Slides: <a href="https://go.wisc.edu/i50k4t">go.wisc.edu/i50k4t</a><br/> - Examples: <a href="https://go.wisc.edu/9416ze">go.wisc.edu/9416ze</a><br/> * Lab Members: Margaret Thairu, Hanying Jiang, Shuchen Yan, Yuliang Peng, Kai Cui, Sam Merten * Funding: NIGMS R01GM152744 --- class: reference ### References [1] G. Alain et al. _Understanding intermediate layers using linear classifier probes_. 2017. URL: [https://openreview.net/forum?id=ryF7rTqgl](https://openreview.net/forum?id=ryF7rTqgl). [2] T. Munzner. _Perception, Frameworks, Color_. InfoVis MiniCourse, Lecture 1. Lecture. Presentation slides available at https://www.cs.ubc.ca/~tmm/talks/bord04.1/bord1.mgp.6up.pdf. Jun. 2004. [3] J. Heer et al. "Crowdsourcing graphical perception: using mechanical turk to assess visualization design". 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This allows us to evaluate model quality by comparing real with simulated samples. <div style="text-align: center;"> <img src="figures/lda_posterior_predictive.jpeg" width=700/> </div> --- ### Figure Credits Microscope by Hilmy Abiyyu Asad from <a href="https://thenounproject.com/browse/icons/term/microscope/" target="_blank" title="Microscope Icons">Noun Project</a> (CC BY 3.0) ---